The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 8, 2026 | Santini Gino | Director | Option exercise(M) | 9K | $16.49 | $143K |
| Jun 8, 2026 | Santini Gino | Director | Option exercise(M) | 9K | — | $0 |
| May 18, 2026 | Freund John Gordon | Director | Sell(S) | 20 | $34.05 | $681 |
| May 15, 2026 | Freund John Gordon | Director | Option exercise(M) | 9K | $16.49 | $143K |
| May 15, 2026 | Freund John Gordon | Director | Sell(S) | 4K | $34.54 | $143K |
| May 15, 2026 | Freund John Gordon | Director | Option exercise(M) | 9K | — | $0 |
| May 14, 2026 | Balice-Gordon Rita J. | Director | Grant(A) | 9K | — | $0 |
| May 14, 2026 | Lurker Nancy | Director | Grant(A) | 9K | — | $0 |
| May 14, 2026 | Paya Carlos V | Director | Grant(A) | 9K | — | $0 |
| May 14, 2026 | Glancy Donovan Michael | Director | Grant(A) | 17K | — | $0 |
| May 14, 2026 | Bohlin Garen G | Director | Grant(A) | 9K | — | $0 |
| May 14, 2026 | Santini Gino | Director | Grant(A) | 9K | — | $0 |
| May 14, 2026 | Freund John Gordon | Director | Grant(A) | 9K | — | $0 |
| May 13, 2026 | Lurker Nancy | Director | Sell(S) | 5K | $35.97 | $162K |
| May 11, 2026 | Bohlin Garen G | Director | Option exercise(M) | 9K | $16.49 | $143K |
| May 11, 2026 | Bohlin Garen G | Director | Sell(S) | 9K | $37.18 | $323K |
| May 11, 2026 | Bohlin Garen G | Director | Option exercise(M) | 9K | — | $0 |
| Mar 18, 2026 | Dieter David | EVP & General Counsel | Sell(S) | 14K | $34.92 | $488K |
| Mar 17, 2026 | Dieter David | EVP & General Counsel | Tax withholding(F) | 9K | $35.72 | $316K |
| Mar 9, 2026 | Dieter David | EVP & General Counsel | Sell(S) | 6K | $36.65 | $228K |
| Mar 3, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 4K | $40.99 | $146K |
| Mar 3, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 46K | $40.36 | $1.9M |
| Feb 10, 2026 | Karnani Vikram | President and CEO, Director | Tax withholding(F) | 11K | $46.75 | $528K |
| Feb 10, 2026 | Karnani Vikram | President and CEO, Director | Grant(A) | 33K | — | $0 |
| Feb 10, 2026 | Karnani Vikram | President and CEO, Director | Grant(A) | 79K | — | $0 |
| Feb 10, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Tax withholding(F) | 22K | $46.75 | $1.0M |
| Feb 10, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Tax withholding(F) | 10K | $46.75 | $466K |
| Feb 10, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Grant(A) | 31K | — | $0 |
| Feb 10, 2026 | Dreyer Scott | EVP & Chief Commercial Officer | Grant(A) | 19K | — | $0 |
| Feb 10, 2026 | Smith Thomas B | EVP and Chief Medical Officer | Tax withholding(F) | 6K | $46.75 | $276K |
| Feb 10, 2026 | Smith Thomas B | EVP and Chief Medical Officer | Tax withholding(F) | 12K | $46.75 | $539K |
| Feb 10, 2026 | Smith Thomas B | EVP and Chief Medical Officer | Grant(A) | 23K | — | $0 |
| Feb 10, 2026 | Smith Thomas B | EVP and Chief Medical Officer | Grant(A) | 14K | — | $0 |
| Feb 10, 2026 | Tupper Colleen | EVP & Chief Financial Officer | Grant(A) | 33K | — | $0 |
| Feb 10, 2026 | Tupper Colleen | EVP & Chief Financial Officer | Grant(A) | 26K | — | $0 |
| Feb 10, 2026 | Tupper Colleen | EVP & Chief Financial Officer | Tax withholding(F) | 12K | $46.75 | $555K |
| Feb 10, 2026 | Tupper Colleen | EVP & Chief Financial Officer | Tax withholding(F) | 27K | $46.75 | $1.2M |
| Feb 10, 2026 | Dieter David | EVP & General Counsel | Grant(A) | 22K | — | $0 |
| Feb 10, 2026 | Dieter David | EVP & General Counsel | Grant(A) | 9K | — | $0 |
| Feb 10, 2026 | Dieter David | EVP & General Counsel | Tax withholding(F) | 3K | $46.75 | $130K |
| Dec 8, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 11K | $47.89 | $533K |
| Dec 8, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 6K | $48.66 | $315K |
| Dec 8, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 18K | $15.90 | $280K |
| Dec 8, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 18K | — | $0 |
| Dec 5, 2025 | Balice-Gordon Rita J. | Director | Sell(S) | 4K | $47.03 | $172K |
| Nov 12, 2025 | Fallon John A. | Director | Option exercise(M) | 15K | $16.49 | $247K |
| Nov 12, 2025 | Fallon John A. | Director | Sell(S) | 35K | $47.21 | $1.6M |
| Nov 12, 2025 | Fallon John A. | Director | Option exercise(M) | 20K | $9.33 | $185K |
| Nov 12, 2025 | Fallon John A. | Director | Option exercise(M) | 20K | — | $0 |
| Nov 12, 2025 | Fallon John A. | Director | Option exercise(M) | 15K | — | $0 |
| Nov 12, 2025 | Karnani Vikram | President and CEO, Director | Tax withholding(F) | 9K | $47.35 | $425K |
| Nov 6, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 25K | $40.38 | $1.0M |
| Nov 6, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 5K | $41.28 | $201K |
| Aug 29, 2025 | Smith Thomas B | EVP and Chief Medical Officer | Sell(S) | 17K | $38.42 | $672K |
| Aug 18, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 16K | $21.34 | $350K |
| Aug 18, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 16K | $38.21 | $626K |
| Aug 18, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 16K | — | $0 |
| Aug 15, 2025 | Santini Gino | Director | Option exercise(M) | 15K | $13.45 | $202K |
| Aug 15, 2025 | Santini Gino | Director | Sell(S) | 5K | $37.19 | $201K |
| Aug 15, 2025 | Santini Gino | Director | Option exercise(M) | 15K | — | $0 |
| Aug 13, 2025 | Rubric Capital Management LP | 10% Owner | Sell(S) | 25K | $37.85 | $946K |
| Aug 13, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 5K | $21.34 | $104K |
| Aug 13, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 5K | $38.03 | $185K |
| Aug 13, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Option exercise(M) | 5K | — | $0 |
| Aug 8, 2025 | Freund John Gordon | Director | Sell(S) | 12K | $34.36 | $401K |
| Jun 9, 2025 | Freund John Gordon | Director | Option exercise(M) | 15K | $13.45 | $202K |
| Jun 9, 2025 | Freund John Gordon | Director | Sell(S) | 7K | $30.62 | $202K |
| Jun 9, 2025 | Freund John Gordon | Director | Option exercise(M) | 15K | — | $0 |
| May 15, 2025 | Paya Carlos V | Director | Grant(A) | 20K | — | $0 |
| May 15, 2025 | Santini Gino | Director | Grant(A) | 10K | — | $0 |
| May 15, 2025 | Freund John Gordon | Director | Grant(A) | 10K | — | $0 |
| May 15, 2025 | Balice-Gordon Rita J. | Director | Grant(A) | 10K | — | $0 |
| May 15, 2025 | Bohlin Garen G | Director | Grant(A) | 10K | — | $0 |
| May 15, 2025 | Lurker Nancy | Director | Grant(A) | 10K | — | $0 |
| May 15, 2025 | Fallon John A. | Director | Grant(A) | 10K | — | $0 |
| Mar 21, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 19K | $30.03 | $567K |
| Mar 21, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 6K | $30.03 | $192K |
| Mar 20, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 2K | $30.00 | $58K |
| Mar 20, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 1K | $30.00 | $36K |
| Mar 17, 2025 | Dieter David | EVP & General Counsel | Grant(A) | 68K | — | $0 |
| Mar 14, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 2K | $30.00 | $68K |
| Mar 14, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 977 | $30.00 | $29K |
| Mar 11, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 10K | $30.01 | $313K |
| Mar 11, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 15K | $30.00 | $462K |
| Mar 7, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 2K | $30.00 | $70K |
| Mar 7, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 2K | $30.00 | $45K |
| Mar 6, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Sell(S) | 26K | $28.50 | $743K |
| Mar 6, 2025 | Dreyer Scott | EVP & Chief Commercial Officer | Sell(S) | 3K | $30.00 | $99K |
| Mar 6, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Sell(S) | 2K | $30.00 | $58K |
| Mar 5, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Sell(S) | 20K | $28.03 | $561K |
| Mar 4, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Sell(S) | 40K | $28.08 | $1.1M |
| Mar 4, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Option exercise(M) | 40K | $24.03 | $961K |
| Mar 4, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Option exercise(M) | 40K | — | $0 |
| Feb 10, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Tax withholding(F) | 10K | $30.52 | $300K |
| Feb 10, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Tax withholding(F) | 25K | $30.52 | $768K |
| Feb 10, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Grant(A) | 29K | — | $0 |
| Feb 10, 2025 | Kuhlmann Shirley R. | EVP and General Counsel | Grant(A) | 41K | — | $0 |
| Feb 10, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Grant(A) | 27K | — | $0 |
| Feb 10, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Grant(A) | 52K | — | $0 |
| Feb 10, 2025 | Tupper Colleen | EVP & Chief Financial Officer | Tax withholding(F) | 22K | $30.52 | $681K |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-03-29 → 2026-07-14. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).