The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 29, 2022 | Monohon Ted | Chief Accounting Officer & VP | Grant(A) | 250K | — | $0 |
| Jun 9, 2022 | Bray June | Director | Grant(A) | 54K | — | $0 |
| Jun 8, 2022 | McLoughlin Margaret | Director | Grant(A) | 27K | — | $0 |
| Jun 8, 2022 | Lamond David | Director | Grant(A) | 27K | — | $0 |
| Jun 8, 2022 | Ryan Una S | Director | Grant(A) | 27K | — | $0 |
| Jun 8, 2022 | Senner Christopher J. | Director | Grant(A) | 27K | — | $0 |
| Jun 6, 2022 | McDowell Caryn Gordon | Chief Legal & Adm. Officer | Tax withholding(F) | 7K | $2.86 | $19K |
| Jun 6, 2022 | McDowell Caryn Gordon | Chief Legal & Adm. Officer | Sell(S) | 11K | $2.86 | $31K |
| Jun 6, 2022 | Holsinger Leslie | EVP, Preclinical Development | Tax withholding(F) | 11K | $2.86 | $31K |
| Jun 6, 2022 | Monohon Ted | Chief Accounting Officer & VP | Tax withholding(F) | 2K | $3.12 | $5K |
| May 19, 2022 | Lamond David | Director | Grant(A) | 200K | — | — |
| May 19, 2022 | Low Philip S | Director | Grant(A) | 455K | — | — |
| May 19, 2022 | Low Philip S | Director | Grant(A) | 64K | — | — |
| May 19, 2022 | Low Philip S | Director | Grant(A) | 22K | — | $0 |
| May 19, 2022 | Hannah Brendan | Chief Business Officer | Grant(A) | 114K | — | $0 |
| May 19, 2022 | Thye Dirk | Chief Executive Officer, Director | Grant(A) | 216K | — | $0 |
| May 19, 2022 | Smith Karen L. | Chief Medical Officer | Grant(A) | 170K | — | $0 |
| Mar 14, 2022 | Sabbagh Marwan | Director | Grant(A) | 22K | — | $0 |
| Mar 3, 2022 | Detke Michael J. | Chief Medical Officer | Grant(A) | 140K | — | $0 |
| Mar 3, 2022 | Holsinger Leslie | EVP, Preclinical Development | Grant(A) | 156K | — | $0 |
| Mar 3, 2022 | Lowe Christopher P. | Interim CEO, COO & CFO | Grant(A) | 175K | — | $0 |
| Mar 3, 2022 | McDowell Caryn Gordon | Chief Legal & Adm. Officer | Grant(A) | 140K | — | $0 |
| Mar 3, 2022 | Monohon Ted | Chief Accounting Officer & VP | Grant(A) | 34K | — | $0 |
| Jan 3, 2022 | Detke Michael J. | Chief Medical Officer | Grant(A) | 125K | — | $0 |
| Jan 3, 2022 | Dominy Stephen S. | Chief Scientific Officer, Director | Grant(A) | 125K | — | $0 |
| Jan 3, 2022 | Holsinger Leslie | EVP, R&D | Grant(A) | 125K | — | $0 |
| Jan 3, 2022 | Lowe Christopher P. | COO & Chief Financial Officer | Grant(A) | 125K | — | $0 |
| Jan 3, 2022 | McDowell Caryn Gordon | Chief Legal & Adm. Officer | Grant(A) | 125K | — | $0 |
| Jan 3, 2022 | Lynch Casey | Chief Executive Officer, Director | Grant(A) | 440K | — | $0 |
| Dec 14, 2021 | Monohon Ted | Chief Accounting Officer | Grant(A) | 50K | — | $0 |
| Nov 18, 2021 | Lynch Casey | Chief Executive Officer, Director | Option exercise(M) | 60K | $0.46 | $28K |
| Nov 18, 2021 | Lynch Casey | Chief Executive Officer, Director | Option exercise(M) | 60K | — | $0 |
| Nov 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 30K | $2.23 | $67K |
| Nov 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 30K | — | $0 |
| Nov 12, 2021 | Dominy Stephen S. | Chief Scientific Officer, Director | Buy(P) | 763 | $14.40 | $11K |
| Oct 8, 2021 | McLoughlin Margaret | Director | Sell(S) | 1K | $88.93 | $89K |
| Oct 8, 2021 | McLoughlin Margaret | Director | Option exercise(M) | 1K | $17.00 | $17K |
| Oct 8, 2021 | McLoughlin Margaret | Director | Option exercise(M) | 1K | — | $0 |
| Oct 5, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 5K | $98.50 | $489K |
| Oct 5, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 5K | $54.85 | $272K |
| Oct 5, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 5K | — | $0 |
| Aug 17, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 30K | — | $0 |
| Aug 17, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 30K | $2.23 | $67K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Option exercise(M) | 6K | — | $0 |
| Aug 16, 2021 | McLoughlin Margaret | Director | Sell(S) | 48 | $98.90 | $5K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Option exercise(M) | 6K | $17.00 | $102K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Sell(S) | 3K | $94.55 | $289K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Sell(S) | 1K | $95.57 | $100K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Sell(S) | 1K | $96.51 | $138K |
| Aug 16, 2021 | McLoughlin Margaret | Director | Sell(S) | 423 | $97.55 | $41K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 22K | — | $0 |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 2K | $96.32 | $224K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Option exercise(M) | 22K | $2.23 | $49K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 9K | $94.23 | $863K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 7K | $95.02 | $697K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 2K | $98.90 | $205K |
| Aug 16, 2021 | Lowe Christopher P. | COO & Chief Financial Officer | Sell(S) | 1K | $97.28 | $107K |
| Aug 10, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 10K | — | $0 |
| Aug 10, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 10K | $2.23 | $22K |
| Aug 10, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 10K | $100.00 | $1.0M |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 17K | — | $0 |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 17K | $2.23 | $39K |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 7K | $56.27 | $391K |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 4K | $55.38 | $241K |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 2K | $54.37 | $90K |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 4K | $53.24 | $209K |
| Jul 7, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 523 | $56.99 | $30K |
| Jul 6, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 13K | — | $0 |
| Jul 6, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 288 | $55.01 | $16K |
| Jul 6, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 8K | $53.91 | $445K |
| Jul 6, 2021 | Detke Michael J. | Chief Medical Officer | Sell(S) | 32K | $53.43 | $1.7M |
| Jul 6, 2021 | Detke Michael J. | Chief Medical Officer | Option exercise(M) | 13K | $2.23 | $28K |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-03-29 → 2026-07-11. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).