The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 16, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Grant(A) | 42K | — | $0 |
| Jul 16, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Grant(A) | 24K | — | $0 |
| Jul 16, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Grant(A) | 10K | — | $0 |
| Jul 16, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Sell(S) | 2K | $114.73 | $215K |
| Jul 16, 2026 | Tray Thomas | Principal Accounting Officer | Grant(A) | 4K | — | $0 |
| Jul 16, 2026 | Tray Thomas | Principal Accounting Officer | Grant(A) | 3K | — | $0 |
| Jul 16, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Grant(A) | 26K | — | $0 |
| Jul 16, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Grant(A) | 15K | — | $0 |
| Jul 16, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Grant(A) | 6K | — | $0 |
| Jul 16, 2026 | Meury William | Chief Executive Officer, Director | Grant(A) | 77K | — | $0 |
| Jul 16, 2026 | Meury William | Chief Executive Officer, Director | Grant(A) | 80K | — | $0 |
| Jul 16, 2026 | Meury William | Chief Executive Officer, Director | Grant(A) | 27K | — | $0 |
| Jul 16, 2026 | Hoffman Richard A. | EVP & General Counsel | Grant(A) | 32K | — | $0 |
| Jul 16, 2026 | Hoffman Richard A. | EVP & General Counsel | Grant(A) | 18K | — | $0 |
| Jul 16, 2026 | Hoffman Richard A. | EVP & General Counsel | Grant(A) | 7K | — | $0 |
| Jul 16, 2026 | Gardner David H | EVP, Chief Strategy Officer | Grant(A) | 32K | — | $0 |
| Jul 16, 2026 | Gardner David H | EVP, Chief Strategy Officer | Grant(A) | 18K | — | $0 |
| Jul 16, 2026 | Gardner David H | EVP, Chief Strategy Officer | Grant(A) | 7K | — | $0 |
| Jul 16, 2026 | Basi Ramitpal K | EVP, Human Resources | Grant(A) | 22K | — | $0 |
| Jul 16, 2026 | Basi Ramitpal K | EVP, Human Resources | Grant(A) | 12K | — | $0 |
| Jul 16, 2026 | Basi Ramitpal K | EVP, Human Resources | Grant(A) | 5K | — | $0 |
| Jul 16, 2026 | Issa Mohamed Khairie | EVP, Head of U.S. Commercial | Grant(A) | 34K | — | $0 |
| Jul 16, 2026 | Issa Mohamed Khairie | EVP, Head of U.S. Commercial | Grant(A) | 20K | — | $0 |
| Jul 16, 2026 | Issa Mohamed Khairie | EVP, Head of U.S. Commercial | Grant(A) | 8K | — | $0 |
| Jul 16, 2026 | Issa Mohamed Khairie | EVP, Head of U.S. Commercial | Sell(S) | 1K | $115.01 | $126K |
| Jul 16, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Grant(A) | 58K | — | $0 |
| Jul 16, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Grant(A) | 34K | — | $0 |
| Jul 16, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Grant(A) | 13K | — | $0 |
| Jul 15, 2026 | Issa Mohamed Khairie | EVP, Head of U.S. Commercial | Tax withholding(F) | 1K | $115.09 | $126K |
| Jul 15, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Tax withholding(F) | 3K | $115.09 | $355K |
| Jul 15, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Sell(S) | 28K | $113.05 | $3.2M |
| Jul 15, 2026 | Tray Thomas | Principal Accounting Officer | Tax withholding(F) | 1K | $115.09 | $126K |
| Jul 15, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Tax withholding(F) | 2K | $115.09 | $174K |
| Jul 15, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Tax withholding(F) | 5K | $115.09 | $570K |
| Jul 14, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Tax withholding(F) | 22K | $114.88 | $2.5M |
| Jul 14, 2026 | Tray Thomas | Principal Accounting Officer | Tax withholding(F) | 692 | $114.88 | $79K |
| Jul 14, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Tax withholding(F) | 437 | $114.88 | $50K |
| Jul 14, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Tax withholding(F) | 18K | $114.88 | $2.1M |
| Jul 2, 2026 | Tray Thomas | Principal Accounting Officer | Tax withholding(F) | 477 | $116.86 | $56K |
| Jul 2, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | Tax withholding(F) | 350 | $116.86 | $41K |
| Jul 2, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Tax withholding(F) | 2K | $116.86 | $254K |
| Jul 2, 2026 | Meury William | Chief Executive Officer, Director | Tax withholding(F) | 5K | $116.86 | $558K |
| Jun 30, 2026 | Clancy Paul J | Director | Grant(A) | 252 | $113.36 | $29K |
| Jun 30, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 400 | — | $0 |
| Jun 30, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 400 | — | $0 |
| Jun 30, 2026 | Harrigan Edmund | Director | Grant(A) | 255 | $113.36 | $29K |
| Jun 8, 2026 | Harrigan Edmund | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Harrigan Edmund | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Clancy Paul J | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Clancy Paul J | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Fouse Jacqualyn A | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Fouse Jacqualyn A | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Bienaime Jean Jacques | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Bienaime Jean Jacques | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | High Katherine A | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | High Katherine A | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Brawley Otis W | Director | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Brawley Otis W | Director | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 2K | — | $0 |
| Jun 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 6K | — | $0 |
| Jun 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 6K | — | $0 |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | Option exercise(M) | 3K | $83.83 | $221K |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | Sell(S) | 3K | $100.00 | $264K |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | Option exercise(M) | 3K | — | $0 |
| Jun 1, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Tax withholding(F) | 25K | $95.59 | $2.4M |
| May 26, 2026 | Tray Thomas | Principal Accounting Officer | Sell(S) | 2K | $97.35 | $200K |
| May 26, 2026 | Bienaime Jean Jacques | Director | Option exercise(M) | 15K | — | $0 |
| May 26, 2026 | Bienaime Jean Jacques | Director | Tax withholding(F) | 13K | $97.10 | $1.3M |
| May 26, 2026 | Bienaime Jean Jacques | Director | Option exercise(M) | 15K | $84.53 | $1.3M |
| May 19, 2026 | Clancy Paul J | Director | Option exercise(M) | 15K | — | $0 |
| May 19, 2026 | Clancy Paul J | Director | Sell(S) | 15K | $94.93 | $1.4M |
| May 19, 2026 | Clancy Paul J | Director | Option exercise(M) | 15K | $84.53 | $1.3M |
| May 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Option exercise(M) | 15K | — | $0 |
| May 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Option exercise(M) | 15K | — | $0 |
| May 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Option exercise(M) | 15K | $84.53 | $1.3M |
| May 8, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Option exercise(M) | 15K | $84.53 | $1.3M |
| May 6, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | Grant(A) | 44K | — | $0 |
| May 6, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Grant(A) | 32K | — | $0 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | Grant(A) | 13K | — | $0 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | Grant(A) | 38K | — | $0 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | Grant(A) | 26K | — | $0 |
| Apr 17, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Option exercise(M) | 13K | — | $0 |
| Apr 17, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Option exercise(M) | 6K | — | $0 |
| Apr 17, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Sell(S) | 19K | $96.50 | $1.8M |
| Apr 17, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Option exercise(M) | 13K | $71.93 | $906K |
| Apr 17, 2026 | Cagnoni Pablo J | President, Global Head of R&D | Option exercise(M) | 6K | $64.25 | $390K |
| Apr 15, 2026 | Meury William | Chief Executive Officer, Director | Option exercise(M) | 125K | — | $0 |
| Mar 31, 2026 | Harrigan Edmund | Director | Grant(A) | 269 | $94.12 | $25K |
| Mar 31, 2026 | Clancy Paul J | Director | Grant(A) | 265 | $94.12 | $25K |
| Mar 31, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 421 | — | $0 |
| Mar 31, 2026 | Baker Bros. Advisors LP | Director, 10% Owner | Grant(A) | 421 | — | $0 |
| Mar 25, 2026 | Trotta Matteo | EVP, GM, Dermatology US | Tax withholding(F) | 537 | $92.23 | $50K |
| Mar 17, 2026 | Cagnoni Pablo J | President, R&D | Option exercise(M) | 12K | $64.25 | $739K |
| Mar 17, 2026 | Cagnoni Pablo J | President, R&D | Option exercise(M) | 7K | $61.18 | $438K |
| Mar 17, 2026 | Cagnoni Pablo J | President, R&D | Sell(S) | 19K | $94.24 | $1.8M |
| Mar 17, 2026 | Cagnoni Pablo J | President, R&D | Option exercise(M) | 12K | — | $0 |
| Mar 17, 2026 | Cagnoni Pablo J | President, R&D | Option exercise(M) | 7K | — | $0 |
| Feb 19, 2026 | Cagnoni Pablo J | President, R&D | Option exercise(M) | 6K | $61.18 | $341K |
| Feb 19, 2026 | Cagnoni Pablo J | President, R&D | Sell(S) | 19K | $100.91 | $1.9M |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-01-04 → 2026-07-21. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).