The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 4, 2026 | Gallagher Carol Giltner | Director | Grant(A) | 42K | — | $0 |
| Jun 4, 2026 | Gallagher Carol Giltner | Director | Gift(G) | 42K | — | $0 |
| Jun 4, 2026 | Gallagher Carol Giltner | Director | Gift(G) | 42K | — | $0 |
| Jun 4, 2026 | Baum Charles M | Director | Grant(A) | 42K | — | $0 |
| Jun 4, 2026 | Flowers Kirsten | Director | Grant(A) | 42K | — | $0 |
| Jun 4, 2026 | Stelzer Laurie | Director | Grant(A) | 42K | — | $0 |
| Jun 4, 2026 | Levine Arnold J | Director | Grant(A) | 42K | — | $0 |
| Mar 5, 2026 | Mack David Henry | President and CEO, Director | Grant(A) | 745K | — | $0 |
| Mar 5, 2026 | Ticktin Robert | General Counsel & COO | Grant(A) | 319K | — | $0 |
| Mar 5, 2026 | Jalota Deepika | Chief Development Officer | Grant(A) | 303K | — | $0 |
| Mar 5, 2026 | Carulli Michael | Chief Financial Officer | Grant(A) | 240K | — | $0 |
| Oct 27, 2025 | Mack David Henry | President and CEO, Director | Option exercise(M) | 221K | $1.37 | $302K |
| Oct 27, 2025 | Mack David Henry | President and CEO, Director | Option exercise(M) | 221K | — | $0 |
| Oct 23, 2025 | OrbiMed Capital GP V LLC | 10% Owner | Sell(S) | 1.0M | $1.52 | $1.5M |
| Sep 10, 2025 | Orbimed Advisors LLC | 10% Owner | Sell(S) | 500K | $1.80 | $900K |
| Jul 1, 2025 | Mack David Henry | President and CEO, Director | Sell(S) | 58K | $1.06 | $62K |
| Jul 1, 2025 | Carulli Michael | Chief Financial Officer | Sell(S) | 28K | $1.06 | $30K |
| Jul 1, 2025 | Jalota Deepika | Chief Development Officer | Sell(S) | 33K | $1.06 | $35K |
| Jul 1, 2025 | Ticktin Robert | General Counsel & COO | Sell(S) | 23K | $1.06 | $25K |
| Jun 5, 2025 | Baum Charles M | Director | Grant(A) | 34K | — | $0 |
| Jun 5, 2025 | Flowers Kirsten | Director | Grant(A) | 34K | — | $0 |
| Jun 5, 2025 | Gallagher Carol Giltner | Director | Grant(A) | 34K | — | $0 |
| Jun 5, 2025 | Gallagher Carol Giltner | Director | Gift(G) | 34K | — | $0 |
| Jun 5, 2025 | Gallagher Carol Giltner | Director | Gift(G) | 34K | — | $0 |
| Jun 5, 2025 | Heyman Richard A. | Director | Grant(A) | 34K | — | $0 |
| Jun 5, 2025 | Levine Arnold J | Director | Grant(A) | 34K | — | $0 |
| Jun 5, 2025 | Stelzer Laurie | Director | Grant(A) | 34K | — | $0 |
| Mar 3, 2025 | Mack David Henry | President and CEO, Director | Grant(A) | 800K | — | $0 |
| Mar 3, 2025 | Jalota Deepika | Chief Development Officer | Grant(A) | 300K | — | $0 |
| Mar 3, 2025 | Carulli Michael | Chief Financial Officer | Grant(A) | 265K | — | $0 |
| Jan 3, 2025 | Mack David Henry | President and CEO, Director | Option exercise(M) | 18K | $0.53 | $9K |
| Jan 3, 2025 | Mack David Henry | President and CEO, Director | Option exercise(M) | 18K | — | $0 |
| Dec 3, 2024 | Mack David Henry | President and CEO, Director | Option exercise(M) | 92K | $0.53 | $49K |
| Dec 3, 2024 | Mack David Henry | President and CEO, Director | Option exercise(M) | 92K | — | $0 |
| Sep 11, 2024 | Carulli Michael | Chief Financial Officer | Sell(S) | 3K | $1.50 | $4K |
| Sep 11, 2024 | Jalota Deepika | Chief Development Officer | Sell(S) | 7K | $1.50 | $11K |
| Aug 13, 2024 | Mack David Henry | President and CEO, Director | Grant(A) | 384K | — | — |
| Aug 13, 2024 | Mack David Henry | President and CEO, Director | Grant(A) | 330K | — | — |
| Aug 13, 2024 | Mack David Henry | President and CEO, Director | Disposed to issuer(D) | 250K | — | — |
| Aug 13, 2024 | Mack David Henry | President and CEO, Director | Disposed to issuer(D) | 135K | — | — |
| Aug 13, 2024 | Mack David Henry | President and CEO, Director | Disposed to issuer(D) | 330K | — | — |
| Aug 13, 2024 | Carulli Michael | Chief Financial Officer | Grant(A) | 41K | — | — |
| Aug 13, 2024 | Carulli Michael | Chief Financial Officer | Grant(A) | 75K | — | — |
| Aug 13, 2024 | Carulli Michael | Chief Financial Officer | Disposed to issuer(D) | 75K | — | — |
| Aug 13, 2024 | Carulli Michael | Chief Financial Officer | Disposed to issuer(D) | 14K | — | — |
| Aug 13, 2024 | Carulli Michael | Chief Financial Officer | Disposed to issuer(D) | 27K | — | — |
| Aug 13, 2024 | Jalota Deepika | Chief Development Officer | Grant(A) | 125K | — | — |
| Aug 13, 2024 | Jalota Deepika | Chief Development Officer | Grant(A) | 91K | — | — |
| Aug 13, 2024 | Jalota Deepika | Chief Development Officer | Disposed to issuer(D) | 125K | — | — |
| Aug 13, 2024 | Jalota Deepika | Chief Development Officer | Disposed to issuer(D) | 23K | — | — |
| Aug 13, 2024 | Jalota Deepika | Chief Development Officer | Disposed to issuer(D) | 68K | — | — |
| Jun 7, 2024 | Gallagher Carol Giltner | Director | Gift(G) | 68K | — | $0 |
| Jun 7, 2024 | Gallagher Carol Giltner | Director | Gift(G) | 68K | — | $0 |
| Jun 6, 2024 | Baum Charles M | Director | Grant(A) | 68K | — | $0 |
| Jun 6, 2024 | Flowers Kirsten | Director | Grant(A) | 68K | — | $0 |
| Jun 6, 2024 | Gallagher Carol Giltner | Director | Grant(A) | 68K | — | $0 |
| Jun 6, 2024 | Heyman Richard A. | Director | Grant(A) | 68K | — | $0 |
| Jun 6, 2024 | Levine Arnold J | Director | Grant(A) | 68K | — | $0 |
| Jun 6, 2024 | Stelzer Laurie | Director | Grant(A) | 68K | — | $0 |
| Jan 18, 2024 | Mack David Henry | President and CEO, Director | Grant(A) | 164K | — | $0 |
| Jan 18, 2024 | Mack David Henry | President and CEO, Director | Grant(A) | 520K | — | $0 |
| Jan 18, 2024 | Carulli Michael | Chief Financial Officer | Grant(A) | 82K | — | $0 |
| Jan 18, 2024 | Carulli Michael | Chief Financial Officer | Grant(A) | 205K | — | $0 |
| Jan 18, 2024 | Jalota Deepika | Chief Development Officer | Grant(A) | 96K | — | $0 |
| Jan 18, 2024 | Jalota Deepika | Chief Development Officer | Grant(A) | 225K | — | $0 |
| Nov 22, 2023 | OrbiMed Genesis GP LLC | 10% Owner | Sell(S) | 88K | $2.23 | $196K |
| Nov 10, 2023 | Mack David Henry | President and CEO, Director | Gift(G) | 85K | — | $0 |
| Nov 10, 2023 | Mack David Henry | President and CEO, Director | Gift(G) | 85K | — | $0 |
| Oct 18, 2023 | Mack David Henry | President and CEO, Director | Option exercise(M) | 198K | $0.53 | $105K |
| Sep 15, 2023 | Alland Leila | Chief Medical Officer | Sell(S) | 6K | $6.62 | $42K |
| Sep 15, 2023 | Jalota Deepika | Chief Development Officer | Sell(S) | 4K | $6.62 | $27K |
| Aug 7, 2023 | Mack David Henry | President and CEO, Director | Option exercise(M) | 198K | — | $0 |
| Aug 7, 2023 | Mack David Henry | President and CEO, Director | Option exercise(M) | 86K | $0.53 | $45K |
| Aug 7, 2023 | Mack David Henry | President and CEO, Director | Option exercise(M) | 86K | — | $0 |
| Jun 8, 2023 | Baum Charles M | Director | Grant(A) | 22K | — | $0 |
| Jun 8, 2023 | Flowers Kirsten | Director | Grant(A) | 22K | — | $0 |
| Jun 8, 2023 | Gallagher Carol Giltner | Director | Gift(G) | 22K | — | $0 |
| Jun 8, 2023 | Gallagher Carol Giltner | Director | Gift(G) | 22K | — | $0 |
| Jun 8, 2023 | Gallagher Carol Giltner | Director | Grant(A) | 22K | — | $0 |
| Jun 8, 2023 | Heyman Richard A. | Director | Grant(A) | 22K | — | $0 |
| Jun 8, 2023 | Levine Arnold J | Director | Grant(A) | 22K | — | $0 |
| Jun 8, 2023 | Stelzer Laurie | Director | Grant(A) | 22K | — | $0 |
| May 12, 2023 | Mack David Henry | President and CEO, Director | Grant(A) | 330K | — | $0 |
| May 12, 2023 | Kung Winston | COO, CFO | Grant(A) | 150K | — | $0 |
| May 12, 2023 | Alland Leila | Chief Medical Officer | Grant(A) | 100K | — | $0 |
| May 12, 2023 | Jalota Deepika | Chief Development Officer | Grant(A) | 125K | — | $0 |
| Nov 25, 2022 | Kung Winston | COO, CFO | Gift(G) | 3K | — | $0 |
| Nov 5, 2022 | Gallagher Carol Giltner | Director | Gift(G) | 39K | — | $0 |
| Nov 5, 2022 | Gallagher Carol Giltner | Director | Gift(G) | 39K | — | $0 |
| Nov 4, 2022 | Gallagher Carol Giltner | Director | Grant(A) | 39K | — | $0 |
| Sep 9, 2022 | Alland Leila | Chief Medical Officer | Grant(A) | 52K | — | $0 |
| Sep 9, 2022 | Jalota Deepika | SVP, Regulatory Affairs and QA | Grant(A) | 34K | — | $0 |
| Jun 2, 2022 | Baum Charles M | Director | Grant(A) | 20K | — | $0 |
| Jun 2, 2022 | Flowers Kirsten | Director | Grant(A) | 20K | — | $0 |
| Jun 2, 2022 | Heyman Richard A. | Director | Grant(A) | 20K | — | $0 |
| Jun 2, 2022 | Levine Arnold J | Director | Grant(A) | 20K | — | $0 |
| Jun 2, 2022 | Stelzer Laurie | Director | Grant(A) | 20K | — | $0 |
| May 26, 2022 | OrbiMed Capital GP V LLC | 10% Owner | Sell(S) | 26K | $15.93 | $418K |
| Apr 27, 2022 | Mack David Henry | President and CEO, Director | Option exercise(M) | 33K | $0.53 | $17K |
| Apr 27, 2022 | Mack David Henry | President and CEO, Director | Option exercise(M) | 33K | — | $0 |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-01-04 → 2026-07-22. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).