The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Feb 14, 2024 | Dahms Bradford D. | President and CFO | Tender(U) | 8K | — | — |
| Feb 14, 2024 | Dahms Bradford D. | President and CFO | Disposed to issuer(D) | 332K | — | — |
| Feb 14, 2024 | Dahms Bradford D. | President and CFO | Disposed to issuer(D) | 18K | — | — |
| Feb 14, 2024 | Dukes Iain D. | Director | Tender(U) | 388K | — | — |
| Feb 14, 2024 | Dukes Iain D. | Director | Disposed to issuer(D) | 36K | — | — |
| Feb 14, 2024 | Dukes Iain D. | Director | Disposed to issuer(D) | 62K | — | — |
| Feb 14, 2024 | Dukes Iain D. | Director | Disposed to issuer(D) | 344K | — | — |
| Feb 14, 2024 | Dukes Iain D. | Director | Disposed to issuer(D) | 3K | — | — |
| Feb 14, 2024 | Gordon Carl L | Director, 10% Owner | Tender(U) | 17.1M | — | — |
| Feb 14, 2024 | Gordon Carl L | Director, 10% Owner | Tender(U) | 651K | — | — |
| Feb 14, 2024 | Gordon Carl L | Director, 10% Owner | Disposed to issuer(D) | 3K | — | — |
| Feb 14, 2024 | Hayden Donald J JR | Director | Tender(U) | 10K | — | — |
| Feb 14, 2024 | Hayden Donald J JR | Director | Disposed to issuer(D) | 3K | — | — |
| Feb 14, 2024 | Orbimed Advisors LLC | Director, 10% Owner | Tender(U) | 651K | — | — |
| Feb 14, 2024 | Orbimed Advisors LLC | Director, 10% Owner | Tender(U) | 17.1M | — | — |
| Feb 14, 2024 | Stein Steven H | Director | Disposed to issuer(D) | 3K | — | — |
| Feb 14, 2024 | Yi Kathy | Director | Disposed to issuer(D) | 3K | — | — |
| Feb 14, 2024 | Yi Kathy | Director | Disposed to issuer(D) | 100K | — | — |
| Nov 6, 2023 | Shakespeare William | See Remarks | Option exercise(M) | 251K | $0.32 | $80K |
| Nov 6, 2023 | Shakespeare William | See Remarks | Option exercise(M) | 251K | — | $0 |
| Jul 17, 2023 | Orbimed Advisors LLC | Director, 10% Owner | Buy(P) | 328K | $3.05 | $1.0M |
| Jul 17, 2023 | Orbimed Advisors LLC | Director, 10% Owner | Buy(P) | 151K | $3.05 | $462K |
| Jul 17, 2023 | Gordon Carl L | Director, 10% Owner | Buy(P) | 151K | $3.05 | $462K |
| Jul 17, 2023 | Gordon Carl L | Director, 10% Owner | Buy(P) | 328K | $3.05 | $1.0M |
| Jul 17, 2023 | Foresite Capital Opportunity Management V, LLC | 10% Owner | Buy(P) | 177K | $2.97 | $524K |
| Jul 17, 2023 | Foresite Capital Opportunity Management V, LLC | 10% Owner | Buy(P) | 523K | $2.97 | $1.6M |
| Jun 13, 2023 | Dukes Iain D. | Director | Grant(A) | 20K | — | $0 |
| Jun 13, 2023 | Dukes Iain D. | Director | Grant(A) | 3K | — | $0 |
| Jun 13, 2023 | Gordon Carl L | Director, 10% Owner | Grant(A) | 20K | — | $0 |
| Jun 13, 2023 | Gordon Carl L | Director, 10% Owner | Grant(A) | 3K | — | $0 |
| Jun 13, 2023 | Hayden Donald J JR | Director | Grant(A) | 20K | — | $0 |
| Jun 13, 2023 | Hayden Donald J JR | Director | Grant(A) | 3K | — | $0 |
| Jun 13, 2023 | Yi Kathy | Director | Grant(A) | 3K | — | $0 |
| Jun 13, 2023 | Yi Kathy | Director | Grant(A) | 20K | — | $0 |
| Jun 13, 2023 | Stein Steven H | Director | Grant(A) | 20K | — | $0 |
| Jun 13, 2023 | Stein Steven H | Director | Grant(A) | 3K | — | $0 |
| Mar 1, 2023 | Clackson Timothy P | President and CEO, Director | Grant(A) | 46K | — | $0 |
| Mar 1, 2023 | Dahms Bradford D. | Chief Financial Officer | Grant(A) | 18K | — | $0 |
| Mar 1, 2023 | Kerstein David | Chief Medical Officer | Grant(A) | 18K | — | $0 |
| Mar 1, 2023 | Shakespeare William | See Remarks | Grant(A) | 21K | — | $0 |
| Mar 1, 2023 | Rivera Victor | Chief Scientific Officer | Grant(A) | 16K | — | $0 |
| Feb 17, 2023 | Clackson Timothy P | President and CEO, Director | Grant(A) | 274K | — | $0 |
| Feb 17, 2023 | Dahms Bradford D. | Chief Financial Officer | Grant(A) | 105K | — | $0 |
| Feb 17, 2023 | Kerstein David | Chief Medical Officer | Grant(A) | 105K | — | $0 |
| Feb 17, 2023 | Rivera Victor | Chief Scientific Officer | Grant(A) | 98K | — | $0 |
| Feb 17, 2023 | Shakespeare William | See Remarks | Grant(A) | 128K | — | $0 |
| Dec 30, 2022 | Hayden Donald J JR | Director | Buy(P) | 10K | $5.00 | $50K |
| Dec 29, 2022 | Hayden Donald J JR | Director | Buy(P) | 100 | $5.00 | $500 |
| Dec 29, 2022 | Foresite Capital Opportunity Management V, LLC | 10% Owner | Buy(P) | 250K | $5.00 | $1.3M |
| Dec 29, 2022 | Foresite Capital Opportunity Management V, LLC | 10% Owner | Buy(P) | 250K | $5.00 | $1.3M |
| Nov 30, 2022 | Dahms Bradford D. | Chief Financial Officer | Buy(P) | 2K | $6.66 | $10K |
| Nov 11, 2022 | Clackson Timothy P | President and CEO, Director | Buy(P) | 3K | $6.80 | $17K |
| Nov 7, 2022 | OrbiMed Genesis GP LLC | Director, 10% Owner | Buy(P) | 192K | $5.21 | $1.0M |
| Nov 7, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 192K | $5.21 | $1.0M |
| Oct 17, 2022 | Stein Steven H | Director | Grant(A) | 60K | — | $0 |
| Jun 10, 2022 | Gordon Carl L | Director, 10% Owner | Grant(A) | 30K | — | $0 |
| Jun 10, 2022 | Dukes Iain D. | Chairman, Director | Grant(A) | 30K | — | $0 |
| Jun 10, 2022 | Dukes Iain D. | Chairman, Director | Grant(A) | 15K | — | $0 |
| Jun 10, 2022 | Yi Kathy | Director | Grant(A) | 30K | — | $0 |
| May 17, 2022 | Hayden Donald J JR | Director | Grant(A) | 60K | — | $0 |
| Feb 18, 2022 | Rivera Victor | Chief Scientific Officer | Grant(A) | 130K | — | $0 |
| Feb 18, 2022 | Shakespeare William | See Remarks | Grant(A) | 180K | — | $0 |
| Feb 18, 2022 | Dahms Bradford D. | Chief Financial Officer | Grant(A) | 150K | — | $0 |
| Feb 18, 2022 | Dalgarno David | Chief Technical Officer | Grant(A) | 130K | — | $0 |
| Feb 18, 2022 | Clackson Timothy P | President and CEO, Director | Grant(A) | 450K | — | $0 |
| Feb 18, 2022 | Kerstein David | Chief Medical Officer | Grant(A) | 150K | — | $0 |
| Jan 21, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 112K | $9.97 | $1.1M |
| Jan 21, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 112K | $9.97 | $1.1M |
| Jan 20, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 35K | $9.95 | $348K |
| Jan 20, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 35K | $9.95 | $348K |
| Jan 19, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 12K | $9.97 | $115K |
| Jan 19, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 12K | $9.97 | $115K |
| Jan 13, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 17K | $9.43 | $163K |
| Jan 13, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 17K | $9.43 | $163K |
| Jan 12, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 19K | $10.06 | $190K |
| Jan 12, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 19K | $10.06 | $190K |
| Jan 11, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 7K | $10.67 | $74K |
| Jan 11, 2022 | OrbiMed Capital GP VII LLC | Director, 10% Owner | Buy(P) | 2K | $9.81 | $16K |
| Jan 11, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 2K | $9.81 | $16K |
| Jan 11, 2022 | Gordon Carl L | Director, 10% Owner | Buy(P) | 7K | $10.67 | $74K |
| Dec 21, 2021 | Dahms Bradford D. | Chief Financial Officer | Buy(P) | 2K | $10.15 | $20K |
| Dec 21, 2021 | Clackson Timothy P | President and CEO, Director | Buy(P) | 3K | $9.76 | $25K |
| Oct 12, 2021 | Paster Anne-Mari | Insider | Buy(P) | 188K | $16.00 | $3.0M |
| Oct 12, 2021 | Paster Anne-Mari | Insider | Conversion(C) | 524K | — | — |
| Oct 12, 2021 | Paster Anne-Mari | Insider | Conversion(C) | 693K | — | — |
| Oct 12, 2021 | Shakespeare William | See Remarks | Buy(P) | 625 | $16.00 | $10K |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Conversion(C) | 15.8M | — | — |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Conversion(C) | 437K | — | — |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Buy(P) | 563K | $16.00 | $9.0M |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Buy(P) | 63K | $16.00 | $1.0M |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Conversion(C) | 873K | — | — |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Conversion(C) | 437K | — | — |
| Oct 12, 2021 | OrbiMed Genesis GP LLC | 10% Owner | Conversion(C) | 14.9M | — | — |
| Oct 12, 2021 | Rock Springs Capital LLC | 10% Owner | Buy(P) | 250K | $16.00 | $4.0M |
| Oct 12, 2021 | Rock Springs Capital LLC | 10% Owner | Conversion(C) | 87K | — | — |
| Oct 12, 2021 | Rock Springs Capital LLC | 10% Owner | Conversion(C) | 349K | — | — |
| Oct 12, 2021 | Rock Springs Capital LLC | 10% Owner | Conversion(C) | 87K | — | — |
| Oct 12, 2021 | Rock Springs Capital LLC | 10% Owner | Conversion(C) | 349K | — | — |
| Oct 12, 2021 | Gordon Carl L | Director, 10% Owner | Buy(P) | 63K | $16.00 | $1.0M |
| Oct 12, 2021 | Gordon Carl L | Director, 10% Owner | Buy(P) | 563K | $16.00 | $9.0M |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-03-29 → 2026-07-14. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).