The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.
| Date | Insider | Role | Action | Shares | Price | Value |
|---|---|---|---|---|---|---|
| May 21, 2026 | Limber Joseph M | Director | Grant(A) | 4K | — | $0 |
| May 21, 2026 | Franklin Heather L | Director | Grant(A) | 4K | — | $0 |
| May 21, 2026 | Hernday Natasha | Director | Grant(A) | 4K | — | $0 |
| May 21, 2026 | Perry Matthew D | Director | Grant(A) | 4K | — | $0 |
| May 21, 2026 | Kosacz Barbara | Director | Grant(A) | 4K | — | $0 |
| May 21, 2026 | Wyszomierski Jack L | Director | Grant(A) | 4K | — | $0 |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 2.3M | $4.03 | $9.3M |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 1.5M | $4.03 | $6.1M |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 412K | $4.03 | $1.7M |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 772K | $4.03 | $3.1M |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 2K | — | $0 |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 2K | — | $0 |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 412 | — | $0 |
| May 14, 2026 | BVF Partners L P | 10% Owner | Conversion(C) | 772 | — | $0 |
| Apr 20, 2026 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 3K | — | $0 |
| Apr 20, 2026 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 3K | — | $0 |
| Apr 20, 2026 | Sitko Bradley | Chief Investment Officer | Option exercise(M) | 4K | — | $0 |
| Apr 20, 2026 | Sitko Bradley | Chief Investment Officer | Option exercise(M) | 4K | — | $0 |
| Apr 20, 2026 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 11K | — | $0 |
| Apr 20, 2026 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 11K | — | $0 |
| Apr 20, 2026 | Trigilio Jeffrey | Chief Financial Officer | Option exercise(M) | 12K | — | $0 |
| Apr 20, 2026 | Trigilio Jeffrey | Chief Financial Officer | Option exercise(M) | 12K | — | $0 |
| Apr 13, 2026 | Trigilio Jeffrey | Chief Financial Officer | Option exercise(M) | 4K | — | $0 |
| Apr 13, 2026 | Trigilio Jeffrey | Chief Financial Officer | Tax withholding(F) | 2K | $36.76 | $60K |
| Apr 13, 2026 | Trigilio Jeffrey | Chief Financial Officer | Option exercise(M) | 4K | — | $0 |
| Mar 27, 2026 | Limber Joseph M | Director | Option exercise(M) | 3K | $11.20 | $34K |
| Mar 27, 2026 | Limber Joseph M | Director | Option exercise(M) | 3K | — | $0 |
| Mar 24, 2026 | Wyszomierski Jack L | Director | Option exercise(M) | 3K | $11.20 | $34K |
| Mar 24, 2026 | Wyszomierski Jack L | Director | Option exercise(M) | 3K | — | $0 |
| Mar 16, 2026 | Hughes Owen | Chief Executive Officer, Director | Grant(A) | 82K | — | $0 |
| Mar 16, 2026 | Hughes Owen | Chief Executive Officer, Director | Grant(A) | 127K | — | $0 |
| Mar 11, 2026 | Montano Maricel Perea | Chief Legal Officer | Grant(A) | 26K | — | $0 |
| Mar 11, 2026 | Montano Maricel Perea | Chief Legal Officer | Grant(A) | 40K | — | $0 |
| Mar 11, 2026 | Trigilio Jeffrey | Chief Financial Officer | Grant(A) | 90K | — | $0 |
| Mar 11, 2026 | Trigilio Jeffrey | Chief Financial Officer | Grant(A) | 138K | — | $0 |
| Mar 11, 2026 | Sitko Bradley | Chief Investment Officer | Grant(A) | 30K | — | $0 |
| Mar 11, 2026 | Sitko Bradley | Chief Investment Officer | Grant(A) | 29K | — | $0 |
| Mar 11, 2026 | Sitko Bradley | Chief Investment Officer | Grant(A) | 45K | — | $0 |
| Jan 12, 2026 | Trigilio Jeffrey | Chief Financial Officer | Grant(A) | 30K | — | $0 |
| Dec 4, 2025 | Hughes Owen | Chief Executive Officer, Director | Buy(P) | 100K | $25.05 | $2.5M |
| Sep 22, 2025 | Burns Thomas M. | SVP, Finance & CFO | Sell(S) | 15 | $36.81 | $552 |
| Sep 22, 2025 | Burns Thomas M. | SVP, Finance & CFO | Sell(S) | 4K | $35.98 | $155K |
| Sep 22, 2025 | Burns Thomas M. | SVP, Finance & CFO | Sell(S) | 15 | $36.93 | $554 |
| Sep 19, 2025 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 3K | — | $0 |
| Sep 19, 2025 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 3K | — | $0 |
| Sep 19, 2025 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 12K | — | $0 |
| Sep 19, 2025 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 12K | — | $0 |
| Sep 19, 2025 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 36K | — | $0 |
| Sep 19, 2025 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 36K | — | $0 |
| Sep 19, 2025 | Sitko Bradley | Chief Investment Officer | Option exercise(M) | 7K | — | $0 |
| Sep 19, 2025 | Sitko Bradley | Chief Investment Officer | Option exercise(M) | 7K | — | $0 |
| Sep 10, 2025 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 9K | — | $0 |
| Sep 10, 2025 | Montano Maricel Perea | Chief Legal Officer | Option exercise(M) | 9K | — | $0 |
| Aug 12, 2025 | Montano Maricel Perea | Chief Legal Officer | Grant(A) | 23K | — | $0 |
| Jun 30, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 2K | $25.39 | $51K |
| May 21, 2025 | Kosacz Barbara | Director | Grant(A) | 6K | — | $0 |
| May 21, 2025 | Franklin Heather L | Director | Grant(A) | 6K | — | $0 |
| May 21, 2025 | Hernday Natasha | Director | Grant(A) | 6K | — | $0 |
| May 21, 2025 | Perry Matthew D | Director | Grant(A) | 6K | — | $0 |
| May 21, 2025 | Limber Joseph M | Director | Grant(A) | 10K | — | $0 |
| May 21, 2025 | Wyszomierski Jack L | Director | Grant(A) | 6K | — | $0 |
| May 21, 2025 | Kosacz Barbara | Director | Grant(A) | 6K | — | $0 |
| May 20, 2025 | Burns Thomas M. | SVP, Finance & CFO | Sell(S) | 10K | $25.38 | $266K |
| May 20, 2025 | Hughes Owen | Chief Executive Officer, Director | Sell(S) | 26K | $25.38 | $651K |
| May 19, 2025 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 18K | — | $0 |
| May 19, 2025 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 18K | — | $0 |
| May 19, 2025 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 53K | — | $0 |
| May 19, 2025 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 53K | — | $0 |
| May 16, 2025 | BVF GP Holdings LLC | 10% Owner | Sell(S) | 127K | $27.10 | $3.5M |
| May 16, 2025 | BVF GP Holdings LLC | 10% Owner | Sell(S) | 265K | $27.10 | $7.2M |
| Apr 7, 2025 | Limber Joseph M | Director | Buy(P) | 5K | $25.60 | $134K |
| Apr 7, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 2K | $24.70 | $49K |
| Apr 4, 2025 | Limber Joseph M | Director | Buy(P) | 3K | $25.25 | $88K |
| Apr 4, 2025 | Limber Joseph M | Director | Buy(P) | 3K | $25.56 | $86K |
| Apr 3, 2025 | Limber Joseph M | Director | Buy(P) | 1K | $25.44 | $36K |
| Apr 3, 2025 | Limber Joseph M | Director | Buy(P) | 17K | $25.22 | $417K |
| Apr 1, 2025 | Burns Thomas M. | SVP, Finance & CFO | Buy(P) | 1K | $25.46 | $25K |
| Mar 31, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 245 | $25.39 | $6K |
| Mar 31, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 1K | $19.98 | $20K |
| Mar 21, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 1K | $20.65 | $28K |
| Mar 21, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 3K | $25.43 | $71K |
| Jan 24, 2025 | Biotechnology Value Fund L P | 10% Owner | Sell(S) | 75K | $26.10 | $2.0M |
| Jan 24, 2025 | Biotechnology Value Fund L P | 10% Owner | Sell(S) | 86K | $26.10 | $2.2M |
| Jan 24, 2025 | Biotechnology Value Fund L P | 10% Owner | Sell(S) | 150K | $26.10 | $3.9M |
| Jan 24, 2025 | Biotechnology Value Fund L P | 10% Owner | Sell(S) | 340K | $26.10 | $8.9M |
| Jan 8, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 313 | $25.60 | $8K |
| Jan 8, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 75 | $25.90 | $2K |
| Jan 8, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 82 | $25.60 | $2K |
| Jan 8, 2025 | Sitko Bradley | Chief Investment Officer | Buy(P) | 75 | $25.60 | $2K |
| Dec 31, 2024 | Sitko Bradley | Chief Investment Officer | Buy(P) | 300 | $25.90 | $8K |
| Nov 13, 2024 | Hughes Owen | Chief Executive Officer, Director | Sell(S) | 22K | $29.95 | $655K |
| Nov 13, 2024 | Burns Thomas M. | SVP, Finance & CFO | Sell(S) | 10K | $29.94 | $293K |
| Nov 11, 2024 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 53K | — | $0 |
| Nov 11, 2024 | Hughes Owen | Chief Executive Officer, Director | Option exercise(M) | 53K | — | $0 |
| Nov 11, 2024 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 18K | — | $0 |
| Nov 11, 2024 | Burns Thomas M. | SVP, Finance & CFO | Option exercise(M) | 18K | — | $0 |
| May 15, 2024 | Limber Joseph M | Director | Grant(A) | 10K | — | $0 |
| May 15, 2024 | Perry Matthew D | Director | Grant(A) | 6K | — | $0 |
| May 15, 2024 | Wyszomierski Jack L | Director | Grant(A) | 6K | — | $0 |
| May 15, 2024 | Franklin Heather L | Director | Grant(A) | 10K | — | $0 |
Insider transactions sourced from SEC EDGAR Form 4 filings, normalized within minutes of acceptance. "Buy"/"Sell" mark open-market transactions (codes P/S), the tradeable signal. Awards, option exercises and tax-withholding are shown with their raw code. All data is public domain.
Coverage: Form 4 filings indexed 2021-03-29 → 2026-07-14. Earlier history is backfilling; this window widens as it deepens.
Programmatic access via the Arkolith API & MCP server (insider.transactions, insider.company).