UPB

Upstream Bio Inc$7.18 8.62%
Health CareUSCUSIP 91678A107· EOD Aug 25, 2026◍ Confluence graph
Tracked 13F Holders
141
-93 QoQ
13F Value (tracked)
$437.4M
Insider Net · 180d
-$77K
0↑ 5↓
Recent Filings
15
Smart-money sentimentMixed
BearishBullish
13F funds (latest Q)35 adding · 14 trimming
Insider net (180d)-$77K

Price & smart-money activity

$7.18 8.62%2Y -57.8%
$3.79$11.52$19.26$27.00$34.73Oct 2024Feb 2025JulNovApr 2026Aug52517141814261640235553651615
Hover for who · click for detailEnd-of-day closing prices52w $5.92 – $32.60

Who owns UPB?

141 tracked 13F filers

141 tracked 13F filers disclose a position in UPB as of the latest SEC 13F filings, a combined $437.4M in reported value. Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

All quarters use one ordinary-share-equivalent series. Historical ADS are converted at 2 ADS = 1 ordinary share. Expand a row for the exact calculation; the residual is not classified as a trade.
1 source-reported value row is withheld because the reported units do not agree with same-security peers. Share counts remain visible and unchanged.
#FundPosition valueSharesLast moveAs ofHistory
1FMR LLC
$72.9M
8.1M
+7.8%
Added · +583K sh
Q1 2026
2ORBIMED ADVISORS LLC
$51.2M
5.7M
Held
Q1 2026
3BlackRock, Inc.
$30.3M
3.4M
+0.8%
Added · +26K sh
Q1 2026
4NORGES BANK
$78.3M
2.9M
+197%
Added · +1.9M sh
Q4 2025
5Enavate Sciences GP, LLC
$22.1M
2.5M
Held
Q1 2026
6VANGUARD CAPITAL MANAGEMENT LLC
$16.9M
1.9M
First observed position
No prior filed position
Q1 2026
7FEDERATED HERMES, INC.
$8.8M
980K
2k×
Added · +979K sh
Q1 2026
8MILLENNIUM MANAGEMENT LLC
$8.4M
937K
+81%
Added · +420K sh
Q1 2026
9GEODE CAPITAL MANAGEMENT, LLC
$6.4M
931K
−2.0%
Reduced · −19K sh
Q2 2026
10SEB Asset Management AB
$6.1M
878K
Held
Q2 2026
11Woodline Partners LP
$7.5M
831K
+9.4%
Added · +71K sh
Q1 2026
12D. E. Shaw & Co., Inc.
$7.4M
820K
30×
Added · +793K sh
Q1 2026
13Parkman Healthcare Partners LLC
$7.1M
787K
−5.7%
Reduced · −48K sh
Q1 2026
14STATE STREET CORP
$5.3M
766K
+8.6%
Added · +61K sh
Q2 2026
15Samsara BioCapital, LLC
$6.6M
736K
Held
Q1 2026
16Pictet Asset Management Holding SA
$6.6M
733K
−5.1%
Reduced · −40K sh
Q1 2026
17VANGUARD PORTFOLIO MANAGEMENT LLC
$6.5M
728K
First observed position
No prior filed position
Q1 2026
18Y-Intercept (Hong Kong) Ltd
$4.8M
694K
−31%
Reduced · −307K sh
Q2 2026
19HSBC HOLDINGS PLC
$5.8M
640K
New
+640K sh
Q1 2026
20Qube Research & Technologies Ltd
$5.6M
619K
New
+619K sh
Q1 2026
21Bain Capital Life Sciences Investors, LLC
$4.2M
601K
−31%
Reduced · −266K sh
Q2 2026
22MORGAN STANLEY
$5.0M
553K
+353%
Added · +431K sh
Q1 2026
23Walleye Capital LLC
$3.4M
498K
New
+498K sh
Q2 2026
24JPMORGAN CHASE & CO
$4.1M
463K
+320%
Added · +353K sh
Q1 2026
25Altshuler Shaham Ltd
$2.6M
380K
Held
Q2 2026

Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

Is UPB being bought or sold by institutions?

Last quarter, 20 funds opened a new position in UPB and 15 added to an existing one, while 14 reduced and 0 exited entirely — based on 13F filings from active, signal-eligible managers (passive index funds and other mechanical holders are excluded from this count).

Opened (NEW)
20
funds
Added
15
funds
Reduced
14
funds
Exited
0
funds

Funds that own UPB also own

CompanyCo-held byCombined value
INTUITIVE SURGICAL INCISRG72 funds$18.0B
MICROSOFT CORPMSFT70 funds$160.9B
ELI LILLY & COLLY70 funds$46.0B
NVIDIA CORPNVDA69 funds$229.1B
AMAZON.COM INCAMZN69 funds$116.0B
BROADCOM INCAVGO69 funds$96.6B
META PLATFORMS INC-CLASS AMETA69 funds$64.0B
LAM RESEARCH CORPLRCX69 funds$20.3B
MICRON TECHNOLOGY INCMU68 funds$21.3B
BOSTON SCIENTIFIC CORPBSX68 funds$8.9B
THERMO FISHER SCIENTIFIC INCTMO67 funds$13.5B
ROSS STORES INCROST67 funds$7.3B

Ranked by how many of UPB's institutional holders also hold each name, a cross-fund conviction signal.

Insider activity (Form 4)

Full insider page →
Buys · 180d
$0
0 insiders
Sells · 180d
$77K
5 insiders
Net
-$77K
10 P/S txns
Signal
Net Selling
open-market
DateInsiderRoleActionSharesValue
Jun 16, 2026Sutherland Everett RandChief Executive Officer, DirectorSell (S)2K$13K
Jun 16, 2026Ambrose AllisonGeneral CounselSell (S)477$3K
Jun 16, 2026Houghton AdamChief Business OfficerSell (S)700$4K
Jun 16, 2026Deykin AaronChief Medical OfficerSell (S)895$5K
Jun 16, 2026GRAY MICHAELCFO and COOSell (S)853$5K
Mar 16, 2026Houghton AdamChief Business OfficerSell (S)699$6K
Mar 16, 2026Ambrose AllisonGeneral CounselSell (S)475$4K
Mar 16, 2026Sutherland Everett RandChief Executive Officer, DirectorSell (S)2K$19K
Mar 16, 2026Deykin AaronChief Medical OfficerSell (S)894$8K
Mar 16, 2026GRAY MICHAELCFO and COOSell (S)852$8K
Oct 15, 2024ORBIMED ADVISORS LLCDirector, 10% OwnerBuy (P)165K$2.8M
Oct 15, 2024ORBIMED ADVISORS LLCDirector, 10% OwnerBuy (P)660K$11.2M

Institutional ownership over time

38 funds-19 since Q4 2024
066131Q4 2024Q2 2025Q4 2025Q2 2026
funds holding aggregate valuelatest $33.1M

Recent filings

15 shown

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Connected entities for UPB

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Ask your agent what changed in UPB

This stock page is the public Follow view. For one current, evidence-backed answer, use capital_change_brief through REST or MCP. It compares tracked 13F changes with qualifying Form 4 activity and cites the SEC evidence.

Copy-paste
curl -H "Authorization: Bearer YOUR_API_KEY" \
  "https://arkolith.com/api/v1/stocks/UPB/capital-change-brief"
Ask your agent
Use Arkolith's capital_change_brief for UPB.
Tell me what changed, whether insider activity
corroborates it, and cite the SEC evidence.

13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for UPB. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes.