UPB

Upstream Bio Inc$7.05 5.11%
Health CareUSCUSIP 91678A107· EOD Jun 5, 2026◍ Confluence graph
Tracked 13F Holders
110
+5 QoQ
13F Value (tracked)
$471.3M
Insider Net · 180d
-$47K
0↑ 5↓
Recent Filings
15
Smart-money sentimentMixed
BearishBullish
13F funds (latest Q)37 adding · 10 trimming
Insider net (180d)-$47K

Price & smart-money activity

$7.05 5.11%2Y -58.5%
$3.95$11.64$19.34$27.03$34.72Oct 2024Feb 2025JunOctFeb 2026Jun522151017132011371754427
Hover for who · click for detailEnd-of-day closing prices52w $7.05 – $32.60
Build

Use UPB data in an agent

The public view is the crawlable proof. The same sourced dataset is available through REST and MCP for agents, research scripts, and back-office tools.

Build

Ask your agent who owns UPB

This stock page is the Follow view. The Build view lets your agent query UPB owners, fund changes, insider filings, and source links through REST or MCP.

Copy-paste
curl -H "Authorization: Bearer YOUR_API_KEY" \
  "https://arkolith.com/api/v1/stocks/UPB"
Ask your agent
Use Arkolith to show who owns UPB,
which funds added or reduced it, and which
SEC filings prove each claim.

Top institutional holders

110 tracked 13F filers
#FundPosition valueSharesLast moveAs ofHistory
1NORGES BANK
$78.3M
2.9M
+197%
Added · +1.9M sh
Q4 2025
2FMR LLC
$72.9M
8.1M
+7.8%
Added · +583K sh
Q1 2026
3VANGUARD GROUP INC
$64.8M
2.4M
−2.2%
Reduced · −54K sh
Q4 2025
4ORBIMED ADVISORS LLC
$51.2M
5.7M
Held
Q1 2026
5BlackRock, Inc.
$30.3M
3.4M
+0.8%
Added · +26K sh
Q1 2026
6VANGUARD CAPITAL MANAGEMENT LLC
$16.9M
1.9M
New
+1.9M sh
Q1 2026
7Y-Intercept (Hong Kong) Ltd
$9.0M
1.0M
21×
Added · +954K sh
Q1 2026
8FEDERATED HERMES, INC.
$8.8M
980K
2k×
Added · +979K sh
Q1 2026
9GEODE CAPITAL MANAGEMENT, LLC
$8.6M
951K
+12%
Added · +99K sh
Q1 2026
10MILLENNIUM MANAGEMENT LLC
$8.4M
937K
+81%
Added · +420K sh
Q1 2026
11SEB Asset Management AB
$7.9M
878K
New
+878K sh
Q1 2026
12Bain Capital Life Sciences Investors, LLC
$7.8M
867K
−35%
Reduced · −462K sh
Q1 2026
13Woodline Partners LP
$7.5M
831K
+9.4%
Added · +71K sh
Q1 2026
14D. E. Shaw & Co., Inc.
$7.4M
820K
30×
Added · +793K sh
Q1 2026
15Pictet Asset Management Holding SA
$6.6M
733K
−5.1%
Reduced · −40K sh
Q1 2026
16VANGUARD PORTFOLIO MANAGEMENT LLC
$6.5M
728K
New
+728K sh
Q1 2026
17STATE STREET CORP
$6.3M
705K
−47%
Reduced · −614K sh
Q1 2026
18HSBC HOLDINGS PLC
$5.8M
640K
New
+640K sh
Q1 2026
19Qube Research & Technologies Ltd
$5.6M
619K
New
+619K sh
Q1 2026
20MORGAN STANLEY
$5.0M
553K
+353%
Added · +431K sh
Q1 2026
21JPMORGAN CHASE & CO
$4.1M
463K
+320%
Added · +353K sh
Q1 2026
22Nantahala Capital Management, LLC
$3.6M
400K
−19%
Reduced · −95K sh
Q1 2026
23Altshuler Shaham Ltd
$3.4M
380K
−72%
Reduced · −961K sh
Q1 2026
24Jump Financial, LLC
$2.9M
319K
New
+319K sh
Q1 2026
25GOLDMAN SACHS GROUP INC
$2.8M
317K
−5.1%
Reduced · −17K sh
Q1 2026

Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

Fund activity: latest quarter

Opened (NEW)
16
funds
Added
21
funds
Reduced
10
funds
Exited
0
funds

Insider activity (Form 4)

Full insider page →
Buys · 180d
$0
0 insiders
Sells · 180d
$47K
5 insiders
Net
-$47K
5 P/S txns
Signal
Net Selling
open-market
DateInsiderRoleActionSharesValue
Jun 9, 2026Fleming Harold EdwardDirectorGrant (A)17K$0
Jun 9, 2026Beckman DaniellaDirectorGrant (A)17K$0
Jun 9, 2026Renaud Ronald C JRDirectorGrant (A)17K$0
Jun 9, 2026Ratcliffe LiamDirectorGrant (A)17K$0
Jun 9, 2026Ruddy Marcella K.DirectorGrant (A)17K$0
Jun 9, 2026Chimovits ErezDirectorGrant (A)17K$0
Mar 16, 2026Ambrose AllisonGeneral CounselSell (S)475$4K
Mar 16, 2026Sutherland Everett RandChief Executive Officer, DirectorSell (S)2K$19K
Mar 16, 2026Deykin AaronChief Medical OfficerSell (S)894$8K
Mar 16, 2026GRAY MICHAELCFO and COOSell (S)852$8K
Mar 16, 2026Houghton AdamChief Business OfficerSell (S)699$6K
Jan 2, 2026Deykin AaronChief Medical OfficerGrant (A)96K$0

Institutional ownership over time

111 funds+58 since Q4 2024
056111Q4 2024Q1 2025Q2 2025Q3 2025Q4 2025Q1 2026
funds holding aggregate valuelatest $351.3M

Funds that own UPB also own

CompanyCo-held byCombined value
ELI LILLY & COLLY41 funds$3.6B
BOSTON SCIENTIFIC CORPBSX41 funds$1.4B
INTUITIVE SURGICAL INCISRG40 funds$1.5B
NVIDIA CORPNVDA39 funds$22.5B
MICROSOFT CORPMSFT39 funds$13.7B
BROADCOM INCAVGO39 funds$8.8B
META PLATFORMS INC-CLASS AMETA39 funds$7.1B
MICRON TECHNOLOGY INCMU39 funds$4.6B
UNITEDHEALTH GROUP INCUNH39 funds$1.3B
GILEAD SCIENCES INCGILD39 funds$1.0B
SERVICENOW INCNOW39 funds$840.0M
AMAZON.COM INCAMZN38 funds$10.7B

Ranked by how many of UPB's institutional holders also hold each name, a cross-fund conviction signal. Via the MCP server (ticker.co_held).

Recent filings

15 shown

Browse more

13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for UPB. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes. Every panel above is one call to the Arkolith API & MCP server.