KPTI

Karyopharm Therapeutics Inc
Health CareUSCUSIP 48576U205◍ Confluence graph
Tracked 13F Holders
82
-44 QoQ
13F Value (tracked)
$128.4M
Insider Net · 180d
-$40K
0↑ 6↓
Recent Filings
15
Smart-money sentimentMixed
BearishBullish
13F funds (latest Q)34 adding · 8 trimming
Insider net (180d)-$40K

Who owns KPTI?

82 tracked 13F filers

82 tracked 13F filers disclose a position in KPTI as of the latest SEC 13F filings, a combined $128.4M in reported value. Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

All quarters use one ordinary-share-equivalent series. Historical ADS are converted at 2 ADS = 1 ordinary share. Expand a row for the exact calculation; the residual is not classified as a trade.
1 source-reported value row is withheld because the reported units do not agree with same-security peers. Share counts remain visible and unchanged.
#FundPosition valueSharesLast moveAs ofHistory
1Commodore Capital LP
$10.9M
1.9M
New
+1.9M sh
Q1 2026
2RA CAPITAL MANAGEMENT, L.P.
$10.7M
1.9M
New
+1.9M sh
Q1 2026
3ADAGE CAPITAL PARTNERS GP, L.L.C.
$10.1M
1.8M
+329%
Added · +1.4M sh
Q1 2026
4T. Rowe Price Investment Management, Inc.
Withheld
1.5M
+3.4%
Added · +51K sh
Q1 2026
5ACORN CAPITAL ADVISORS, LLC
$14.8M
1.5M
+427%
Added · +1.2M sh
Q2 2026
6GOLDMAN SACHS GROUP INC
$5.3M
948K
New
+948K sh
Q1 2026
7Catalio Capital Management, LP
$9.2M
941K
+4.8%
Added · +43K sh
Q2 2026
8VANGUARD CAPITAL MANAGEMENT LLC
$4.1M
740K
First observed position
No prior filed position
Q1 2026
9Ikarian Capital, LLC
$4.1M
733K
+35%
Added · +189K sh
Q1 2026
10Kalehua Capital Management LLC
$6.7M
686K
New
+686K sh
Q2 2026
11GEODE CAPITAL MANAGEMENT, LLC
$5.2M
531K
+158%
Added · +325K sh
Q2 2026
12Ghisallo Capital Management LLC
$4.9M
500K
New
+500K sh
Q2 2026
13Affinity Asset Advisors, LLC
$2.8M
500K
−44%
Reduced · −390K sh
Q1 2026
14Avidity Partners Management LP
$2.6M
464K
+245%
Added · +329K sh
Q1 2026
15Soleus Capital Management, L.P.
$4.3M
440K
Held
Q2 2026
16MILLENNIUM MANAGEMENT LLC
$2.3M
421K
New
+421K sh
Q1 2026
17STATE STREET CORP
$3.2M
326K
+304%
Added · +245K sh
Q2 2026
18Boxer Capital Management, LLC
$1.7M
303K
+20%
Added · +50K sh
Q1 2026
19DAVIDSON KEMPNER CAPITAL MANAGEMENT LP
$1.7M
300K
−3.2%
Reduced · −10K sh
Q1 2026
20SILVERARC CAPITAL MANAGEMENT, LLC
$2.9M
297K
New
+297K sh
Q2 2026
21Eversept Partners, LP
$2.7M
276K
Held
Q2 2026
22Jump Financial, LLC
$1.5M
262K
+387%
Added · +208K sh
Q1 2026
23Trexquant Investment LP
$1.4M
258K
+518%
Added · +216K sh
Q1 2026
24BlackRock, Inc.
$1.4M
245K
−1.1%
Reduced · −3K sh
Q1 2026
25BOOTHBAY FUND MANAGEMENT, LLC
$1.2M
214K
+48%
Added · +69K sh
Q1 2026

Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

Is KPTI being bought or sold by institutions?

Last quarter, 16 funds opened a new position in KPTI and 18 added to an existing one, while 8 reduced and 0 exited entirely — based on 13F filings from active, signal-eligible managers (passive index funds and other mechanical holders are excluded from this count).

Opened (NEW)
16
funds
Added
18
funds
Reduced
8
funds
Exited
0
funds

Funds that own KPTI also own

CompanyCo-held byCombined value
ELI LILLY & COLLY33 funds$15.4B
UNITEDHEALTH GROUP INCUNH32 funds$7.9B
NVIDIA CORPNVDA31 funds$79.2B
MICROSOFT CORPMSFT30 funds$50.4B
AMAZON.COM INCAMZN30 funds$34.8B
ORACLE CORPORCL30 funds$3.7B
BRISTOL-MYERS SQUIBB COBMY30 funds$2.2B
REVOLUTION MEDICINES INCRVMD30 funds$1.3B
META PLATFORMS INC-CLASS AMETA29 funds$23.7B
VISA INC-CLASS A SHARESV29 funds$14.2B
JPMORGAN CHASE & COJPM29 funds$11.0B
GENERAL ELECTRICGE29 funds$7.7B

Ranked by how many of KPTI's institutional holders also hold each name, a cross-fund conviction signal.

Insider activity (Form 4)

Full insider page →
Buys · 180d
$0
0 insiders
Sells · 180d
$40K
6 insiders
Net
-$40K
9 P/S txns
Signal
Net Selling
open-market
DateInsiderRoleActionSharesValue
Sep 1, 2026Abate KristinChief Accounting OfficerSell (S)19$38
Jul 28, 2026Poulton StuartEVP, Chief Development OfficerSell (S)189$1K
May 14, 2026Cheng Sohanya RoshanEVP & Chief Commercial OfficerSell (S)324$3K
May 14, 2026Abate KristinChief Accounting OfficerSell (S)53$504
May 14, 2026Paulson Richard A.President and CEO, DirectorSell (S)2K$21K
May 14, 2026Mano MichaelEVP, CLO&SecretarySell (S)266$3K
May 14, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)408$4K
May 14, 2026Poulton StuartEVP, Chief Development OfficerSell (S)403$4K
Apr 21, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)449$4K
Mar 2, 2026Paulson Richard A.President and CEO, DirectorSell (S)12K$116K
Mar 2, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)5K$48K
Mar 2, 2026Mano MichaelEVP, CLO&SecretarySell (S)4K$33K

Institutional ownership over time

27 funds-12 since Q1 2025
03671Q1 2025Q2 2025Q3 2025Q4 2025Q1 2026Q2 2026
funds holding aggregate valuelatest $47.1M

Share classes

Class13F holdersValue held
KPTIthis pageStock82 funds$128.4M
KPTIEURCOM1 funds$420K

Same issuer, multiple share classes. The consensus leaderboards count this company once across all classes; this is the per-class detail.

Recent filings

15 shown

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Ask your agent what changed in KPTI

This stock page is the public Follow view. For one current, evidence-backed answer, use capital_change_brief through REST or MCP. It compares tracked 13F changes with qualifying Form 4 activity and cites the SEC evidence.

Copy-paste
curl -H "Authorization: Bearer YOUR_API_KEY" \
  "https://arkolith.com/api/v1/stocks/KPTI/capital-change-brief"
Ask your agent
Use Arkolith's capital_change_brief for KPTI.
Tell me what changed, whether insider activity
corroborates it, and cite the SEC evidence.

13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for KPTI. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes.