KPTI

Karyopharm Therapeutics Inc$9.38 1.57%
Health CareUSCUSIP 48576U205· EOD Jul 16, 2026◍ Confluence graph
Tracked 13F Holders
68
+5 QoQ
13F Value (tracked)
$85.9M
Insider Net · 180d
-$346K
0↑ 7↓
Recent Filings
15
Smart-money sentimentMixed
BearishBullish
13F funds (latest Q)30 adding · 4 trimming
Insider net (180d)-$346K

Price & smart-money activity

$9.38 1.57%5Y -93.3%
$3.44$51.11$98.77$146.44$194.10202120222023202420252026191533121646291436528672381029137
Hover for who · click for detailEnd-of-day closing prices52w $3.77 – $10.67

Top institutional holders

68 tracked 13F filers
1 source-reported value row is withheld because the reported units do not agree with same-security peers. Share counts remain visible and unchanged.
#FundPosition valueSharesLast moveAs ofHistory
1Commodore Capital LP
$10.9M
1.9M
New
+1.9M sh
Q1 2026
2RA CAPITAL MANAGEMENT, L.P.
$10.7M
1.9M
New
+1.9M sh
Q1 2026
3ADAGE CAPITAL PARTNERS GP, L.L.C.
$10.1M
1.8M
+329%
Added · +1.4M sh
Q1 2026
4T. Rowe Price Investment Management, Inc.
Withheld
1.5M
+3.4%
Added · +51K sh
Q1 2026
5GOLDMAN SACHS GROUP INC
$5.3M
948K
New
+948K sh
Q1 2026
6Catalio Capital Management, LP
$5.0M
898K
+528%
Added · +755K sh
Q1 2026
7VANGUARD CAPITAL MANAGEMENT LLC
$4.1M
740K
New
+740K sh
Q1 2026
8Ikarian Capital, LLC
$4.1M
733K
+35%
Added · +189K sh
Q1 2026
9Affinity Asset Advisors, LLC
$2.8M
500K
−44%
Reduced · −390K sh
Q1 2026
10Avidity Partners Management LP
$2.6M
464K
+245%
Added · +329K sh
Q1 2026
11Soleus Capital Management, L.P.
$2.5M
440K
Held
Q1 2026
12MILLENNIUM MANAGEMENT LLC
$2.3M
421K
New
+421K sh
Q1 2026
13Boxer Capital Management, LLC
$1.7M
303K
+20%
Added · +50K sh
Q1 2026
14DAVIDSON KEMPNER CAPITAL MANAGEMENT LP
$1.7M
300K
−3.2%
Reduced · −10K sh
Q1 2026
15ACORN CAPITAL ADVISORS, LLC
$1.6M
288K
New
+288K sh
Q1 2026
16Eversept Partners, LP
$1.5M
276K
New
+276K sh
Q1 2026
17Jump Financial, LLC
$1.5M
262K
+387%
Added · +208K sh
Q1 2026
18Trexquant Investment LP
$1.4M
258K
+518%
Added · +216K sh
Q1 2026
19BlackRock, Inc.
$1.4M
245K
−1.1%
Reduced · −3K sh
Q1 2026
20BOOTHBAY FUND MANAGEMENT, LLC
$1.2M
214K
+48%
Added · +69K sh
Q1 2026
21GEODE CAPITAL MANAGEMENT, LLC
$1.1M
206K
+9.8%
Added · +18K sh
Q1 2026
22UBS Group AG
$1.1M
194K
+119%
Added · +106K sh
Q1 2026
23GROUP ONE TRADING LLC
$1.1M
192K
+87%
Added · +89K sh
Q1 2026
24XTX Topco Ltd
$916K
164K
14×
Added · +153K sh
Q1 2026
25TWO SIGMA INVESTMENTS, LP
$842K
151K
+1.6%
Added · +2K sh
Q1 2026

Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

Fund activity: latest quarter

Opened (NEW)
13
funds
Added
17
funds
Reduced
4
funds
Exited
0
funds

Funds that own KPTI also own

CompanyCo-held byCombined value
TERNS PHARMACEUTICALS INC43015 funds$83.0M
MICROSOFT CORPMSFT14 funds$4.1B
CVS HEALTH CORPCVS14 funds$248.8M
AMAZON.COM INCAMZN13 funds$3.1B
BROADCOM INCAVGO13 funds$2.0B
ELI LILLY & COLLY13 funds$1.2B
UNITEDHEALTH GROUP INCUNH13 funds$760.3M
RTX CORPRTX13 funds$445.2M
BOSTON SCIENTIFIC CORPBSX13 funds$287.8M
CENTENE CORPCNC13 funds$170.7M
INSPIRE MEDICAL SYSTEMS INCINSP13 funds$99.6M
ELEVANCE HEALTH INCELV13 funds$89.7M

Ranked by how many of KPTI's institutional holders also hold each name, a cross-fund conviction signal.

Insider activity (Form 4)

Full insider page →
Buys · 180d
$0
0 insiders
Sells · 180d
$346K
7 insiders
Net
-$346K
16 P/S txns
Signal
Net Selling
open-market
DateInsiderRoleActionSharesValue
May 14, 2026Cheng Sohanya RoshanEVP & Chief Commercial OfficerSell (S)324$3K
May 14, 2026Abate KristinChief Accounting OfficerSell (S)53$504
May 14, 2026Paulson Richard A.President and CEO, DirectorSell (S)2K$21K
May 14, 2026Mano MichaelEVP, CLO&SecretarySell (S)266$3K
May 14, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)408$4K
May 14, 2026Poulton StuartEVP, Chief Development OfficerSell (S)403$4K
Apr 21, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)449$4K
Mar 2, 2026Paulson Richard A.President and CEO, DirectorSell (S)12K$116K
Mar 2, 2026Rangwala ReshmaEVP & Chief Medical OfficerSell (S)5K$48K
Mar 2, 2026Mano MichaelEVP, CLO&SecretarySell (S)4K$33K
Mar 2, 2026Cheng Sohanya RoshanEVP & Chief Commercial OfficerSell (S)5K$43K
Mar 2, 2026Poulton StuartEVP, Chief Development OfficerSell (S)5K$48K

Institutional ownership over time

67 funds+30 since Q1 2025
03467Q1 2025Q2 2025Q3 2025Q4 2025Q1 2026
funds holding aggregate valuelatest $85.8M · 1 values withheld

Recent filings

15 shown

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13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for KPTI. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes.