Arkolith/Funds/Ra Capital Management, L.P.

Ra Capital Management, L.P.

CIK 1346824
Holdings as of Mar 31, 2026·disclosed May 15, 2026·~45-day 13F lag·13F-HR
Active Filer

Ra Capital Management, L.P. holds a focused book of 85 stocks worth $9.4B as of Q1 2026 (disclosed May 15, 2026, a ~45-day 13F lag). This quarter they opened Spyglass Pharma Inc and trimmed 4D Molecular Therapeutics In. Their largest long position is Ascendis Pharma A/s at 25% of the equity book.

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Use Arkolith to show RA CAPITAL MANAGEMENT, L.P.'s latest
holdings, largest changes, and filing provenance.
Opened
24
new positions
Added to
17
existing
Trimmed
2
reduced
Sold out
10
exited

Concentration

Top-heavy: focused book

Top 5 holdings
47%
Top 10 holdings
61%
Top 20 holdings
77%

Share of the disclosed book in its largest positions. A higher top-5 share means a more concentrated, higher-conviction portfolio.

Direct sector allocation

75% mapped to company sectors

Health Care
75%
ETF / fund or unclassified
25%
Information Technology
0%
Financials
0%

Direct operating-company sectors from our SIC-based security master. ETF/fund and unclassified holdings stay visible separately; this is not ETF look-through exposure.

Biggest moves: latest quarter

Estimated $ traded · quarter-end prices, no cost basis

Bought
Trimmed / exited

Holdings: largest first

Bars show each stock's share of the portfolio. Click a row for its position history.

85 positions
#SecurityValueShares% PortLast moveHistory
1Ascendis Pharma A/s - ADR
SPONSORED ADR
$2.4B10.28M
24.9%
Held
2Vaxcyte Inc
COMMON STOCK
$666.8M11.47M
7.1%
+7.0%
Added · +750K sh
3Rhythm Pharmaceuticals Inc
COMMON STOCK
$579.8M6.67M
6.1%
Held
4Tyra Biosciences Inc
COMMON STOCK
$467.2M12.20M
5.0%
Held
5Sionna Therapeutics Inc
COMMON STOCK
$397.1M9.91M
4.2%
Held
6Edgewise Therapeutics Inc
COMMON STOCK
$328.5M10.43M
3.5%
Held
7Newamsterdam Pharma Co NV
COMMON STOCK
$305.7M9.55M
3.2%
Held
8Nuvalent Inc-A
COMMON STOCK
$259.6M2.53M
2.8%
+35%
Added · +654K sh
9Dianthus Therapeutics Inc
COMMON STOCK
$219.2M2.61M
2.3%
+62%
Added · +1.0M sh
10Mineralys Therapeutics Inc
COMMON STOCK
$208.4M7.69M
2.2%
+5.0%
Added · +369K sh
11Spyglass Pharma Inc
COMMON STOCK
$207.8M8.02M
2.2%
New
New position
12Wave Life Sciences Ltd
COMMON STOCK
$195.6M26.98M
2.1%
+48%
Added · +8.8M sh
13Septerna Inc
COMMON STOCK
$168.1M7.00M
1.8%
Held
14Disc Medicine Inc
COMMON STOCK
$156.7M2.45M
1.7%
+24%
Added · +474K sh
15Janux Therapeutics Inc
COMMON STOCK
$155.5M11.19M
1.6%
Held
16Biocryst Pharmaceuticals Inc
COMMON STOCK
$150.7M15.83M
1.6%
Held
17Bicara Therapeutics Inc
COMMON STOCK
$144.3M7.26M
1.5%
+4.3%
Added · +300K sh
18Praxis Precision Medicines I
COMMON STOCK
$120.4M373.8K
1.3%
Held
19GH Research PLC
COMMON STOCK
$107.9M7.68M
1.1%
Held
20Zai Lab Ltd-ADR
COMMON STOCK
$107.4M5.71M
1.1%
New
New position
21Taysha Gene Therapies Inc
COMMON STOCK
$105.3M23.56M
1.1%
Held
22Vor Biopharma Inc
COMMON STOCK
$96.4M5.40M
1.0%
Held
23Geron Corp
COMMON STOCK
$95.0M63.77M
1.0%
Held
24Ars Pharmaceuticals Inc
COMMON STOCK
$87.2M10.86M
0.9%
Held
25Sarepta Therapeutics Inc
COMMON STOCK
$84.9M3.90M
0.9%
New
New position
26Spyre Therapeutics Inc
COMMON STOCK
$81.8M1.62M
0.9%
Held
27Evommune Inc
COMMON STOCK
$80.3M3.49M
0.9%
+1.0%
Added · +36K sh
28Climb Bio Inc
COMMON STOCK
$77.4M11.30M
0.8%
+0.1%
Added · +7K sh
29Solid Biosciences Inc
COMMON STOCK
$67.2M9.34M
0.7%
+61%
Added · +3.5M sh
30Artiva Biotherapeutics Inc
COMMON STOCK
$63.5M9.85M
0.7%
Held
31Damora Therapeutics Inc
COMMON STOCK
$62.1M2.40M
0.7%
New
New position
32Xencor Inc
COMMON STOCK
$59.1M4.90M
0.6%
New
New position
33LB Pharmaceuticals Inc
COMMON STOCK
$54.5M2.21M
0.6%
Held
34Jade Biosciences Inc
COMMON STOCK
$51.6M3.67M
0.5%
Held
35Acumen Pharmaceuticals Inc
COMMON STOCK
$49.5M20.99M
0.5%
+41%
Added · +6.1M sh
364D Molecular Therapeutics In
COMMON STOCK
$47.0M5.05M
0.5%
−11%
Reduced · −603K sh
37Fulcrum Therapeutics Inc
COMMON STOCK
$46.4M6.05M
0.5%
Held
38Capricor Therapeutics Inc
COMMON STOCK
$45.8M1.51M
0.5%
Held
39Century Therapeutics Inc
COMMON STOCK
$40.1M17.75M
0.4%
New
New position
40Olema Pharmaceuticals Inc
COMMON STOCK
$38.8M2.60M
0.4%
Held
41Lenz Therapeutics Inc
COMMON STOCK
$38.2M4.18M
0.4%
Held
42Monopar Therapeutics Inc
COMMON STOCK
$36.6M667.2K
0.4%
Held
43Pepgen Inc
COMMON STOCK
$35.5M20.06M
0.4%
Held
44Design Therapeutics Inc
COMMON STOCK
$31.6M2.97M
0.3%
+103%
Added · +1.5M sh
45Mirum Pharmaceuticals Inc
COMMON STOCK
$29.4M318.6K
0.3%
New
New position
46Bioage Labs Inc
COMMON STOCK
$28.9M1.65M
0.3%
New
New position
47Lexeo Therapeutics Inc
COMMON STOCK
$28.7M5.00M
0.3%
Held
48Assembly Biosciences Inc
COMMON STOCK
$28.3M1.02M
0.3%
Held
49Rezolute Inc
COMMON STOCK
$28.0M9.18M
0.3%
Held
50Aktis Oncology Inc
COMMON STOCK
$26.9M1.50M
0.3%
New
New position
Showing 50 of 85 positions

Filing history

As-of date vs the date the SEC received each filing

QuarterAs ofFiledPositionsValueForm
Q1 2026Mar 31, 2026May 15, 202686$9.4B13F-HR
Q4 2025Dec 31, 2025Feb 17, 202672$9.8B13F-HR
Q3 2025Sep 30, 2025Nov 14, 202568$8.1B13F-HR
Q2 2025Jun 30, 2025Aug 14, 202564$5.9B13F-HR
Q1 2025Mar 31, 2025May 15, 202586$6.0B13F-HR
Q4 2024Dec 31, 2024Feb 14, 202590$7.5B13F-HR
Q3 2024Sep 30, 2024Nov 14, 202482$8.7B13F-HR
Q2 2024Jun 30, 2024Aug 14, 202479$7.6B13F-HR
Q1 2024Mar 31, 2024May 17, 202476$7.9B13F-HR/A
Q4 2023Dec 31, 2023Feb 14, 202462$6.4B13F-HR
Q3 2023Sep 30, 2023Nov 15, 202366$5.1B13F-HR/A
Q2 2023Jun 30, 2023Aug 14, 202354$5.3B13F-HR
Q1 2023Mar 31, 2023May 15, 202359$4.4B13F-HR
Q4 2022Dec 31, 2022Feb 14, 202370$4.9B13F-HR
Q3 2022Sep 30, 2022Nov 14, 202281$4.7B13F-HR
Q2 2022Jun 30, 2022Aug 15, 202288$3.8B13F-HR
Q1 2022Mar 31, 2022May 16, 202296$4.6B13F-HR
Q4 2021Dec 31, 2021Feb 14, 202297$5.7B13F-HR
Q3 2021Sep 30, 2021Nov 15, 202195$7.2B13F-HR
Q2 2021Jun 30, 2021Aug 16, 202192$6.2B13F-HR
Q1 2021Mar 31, 2021May 17, 202182$6.6B13F-HR
Q4 2020Dec 31, 2020Feb 16, 202182$7.2B13F-HR
Amended / restated
  • Q1 2024 · filed May 15, 202413F-HR · superseded
  • Q3 2023 · filed Nov 14, 202313F-HR · superseded

Data source

Holdings from SEC EDGAR 13F-HR filings, updated quarterly ~45 days after quarter-end. Public domain. The book and weighting are long equity only; disclosed put/call options are listed separately and excluded from those totals. Price-derived performance is withheld until the price-source policy and freshness gate are green.