This stock page is the public Follow view. For one current, evidence-backed answer, use capital_change_brief through REST or MCP. It compares tracked 13F changes with qualifying Form 4 activity and cites the SEC evidence.
curl -H "Authorization: Bearer YOUR_API_KEY" \ "https://arkolith.com/api/v1/stocks/SYRE/capital-change-brief"
Use Arkolith's capital_change_brief for SYRE. Tell me what changed, whether insider activity corroborates it, and cite the SEC evidence.
| # | Fund | Position value | Shares | Last move | As of | History |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | $594.2M | 11.8M | ▲+1.2% Added · +142K sh | Q1 2026 | |
| 2 | BlackRock, Inc. | $278.5M | 5.5M | ▼~0% Reduced · −880 sh | Q1 2026 | |
| 3 | RTW INVESTMENTS, LP | $210.4M | 4.2M | —Held | Q1 2026 | |
| 4 | Fairmount Funds Management LLC | $202.7M | 4.0M | —Held | Q1 2026 | |
| 5 | PERCEPTIVE ADVISORS LLC | $190.8M | 3.8M | ▲+23% Added · +714K sh | Q1 2026 | |
| 6 | Venrock Adviser, LLC | $185.9M | 3.7M | —Held | Q1 2026 | |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | $154.2M | 3.1M | ▲New +3.1M sh | Q1 2026 | |
| 8 | STATE STREET CORP | $131.5M | 2.6M | ▲+15% Added · +344K sh | Q1 2026 | |
| 9 | Paradigm Biocapital Advisors LP | $98.7M | 2.0M | ▲+33% Added · +490K sh | Q1 2026 | |
| 10 | Commodore Capital LP | $96.5M | 1.9M | ▼−20% Reduced · −476K sh | Q1 2026 | |
| 11 | TCG Crossover Management, LLC | $95.9M | 1.9M | —Held | Q1 2026 | |
| 12 | TANG CAPITAL MANAGEMENT LLC | $95.4M | 1.9M | —Held | Q1 2026 | |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | $86.8M | 1.7M | ▲+3.7% Added · +62K sh | Q1 2026 | |
| 14 | JANUS HENDERSON GROUP PLC | $83.6M | 1.7M | ▼−9.4% Reduced · −173K sh | Q1 2026 | |
| 15 | RA CAPITAL MANAGEMENT, L.P. | $81.8M | 1.6M | —Held | Q1 2026 | |
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | $80.6M | 1.6M | ▼−0.2% Reduced · −3K sh | Q1 2026 | |
| 17 | Remedium Capital Partners, LLC | $73.5M | 1.5M | —Held | Q1 2026 | |
| 18 | Affinity Asset Advisors, LLC | $64.5M | 1.3M | ▼−11% Reduced · −153K sh | Q1 2026 | |
| 19 | BANK OF AMERICA CORP /DE/ | $61.9M | 1.2M | ▲+193% Added · +808K sh | Q1 2026 | |
| 20 | BAKER BROS. ADVISORS LP | $50.4M | 1.0M | —Held | Q1 2026 | |
| 21 | JPMORGAN CHASE & CO | $44.5M | 979K | ▲16× Added · +916K sh | Q1 2026 | |
| 22 | BRAIDWELL LP | $47.1M | 933K | ▼−43% Reduced · −702K sh | Q1 2026 | |
| 23 | FRANKLIN RESOURCES INC | $44.5M | 883K | ▼−20% Reduced · −226K sh | Q1 2026 | |
| 24 | Caligan Partners LP | $44.3M | 878K | ▲New +878K sh | Q1 2026 | |
| 25 | Siren, L.L.C. | $41.3M | 819K | —Held | Q1 2026 |
Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.
| Date | Insider | Role | Action | Shares | Value |
|---|---|---|---|---|---|
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | Option exercise (M) | 8K | $109K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell (S) | 6K | $506K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell (S) | 2K | $152K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | Option exercise (M) | 8K | $0 |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | Option exercise (M) | 8K | $229K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | Sell (S) | 7K | $569K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | Sell (S) | 2K | $162K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | Option exercise (M) | 8K | $0 |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer, Director | Sell (S) | 10K | $890K |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer, Director | Sell (S) | 4K | $373K |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer, Director | Sell (S) | 590 | $52K |
| Jun 25, 2026 | Burrows Scott L | Chief Financial Officer | Option exercise (M) | 15K | $218K |
| Company | Co-held by | Combined value |
|---|---|---|
| META PLATFORMS INC-CLASS AMETA | 48 funds | $13.5B |
| BOSTON SCIENTIFIC CORPBSX | 48 funds | $1.8B |
| MIRUM PHARMACEUTICALS INCMIRM | 48 funds | $695.3M |
| NVIDIA CORPNVDA | 47 funds | $44.8B |
| MICROSOFT CORPMSFT | 47 funds | $29.4B |
| AMAZON.COM INCAMZN | 47 funds | $21.8B |
| BROADCOM INCAVGO | 47 funds | $17.1B |
| ELI LILLY & COLLY | 47 funds | $7.4B |
| NUVALENT INC-ANUVL | 47 funds | $3.2B |
| INTUITIVE SURGICAL INCISRG | 47 funds | $2.6B |
| ALPHABET INC-CL AGOOGL | 46 funds | $18.7B |
| REVOLUTION MEDICINES INCRVMD | 46 funds | $2.6B |
Ranked by how many of SYRE's institutional holders also hold each name, a cross-fund conviction signal. Via the MCP server (ticker.co_held).
13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for SYRE. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes. Every panel above is one call to the Arkolith API & MCP server.