SEPN

Septerna Inc$31.56 7.37%
Health CareUSCUSIP 81734D104· EOD Jul 16, 2026◍ Confluence graph
Tracked 13F Holders
107
+5 QoQ
13F Value (tracked)
$734.9M
Insider Net · 180d
-$3.8M
0↑ 3↓
Recent Filings
15
Smart-money sentimentMixed
BearishBullish
13F funds (latest Q)30 adding · 16 trimming
Insider net (180d)-$3.8M

Price & smart-money activity

$31.56 7.37%2Y +75.3%
$2.50$11.65$20.79$29.94$39.09Oct 2024Mar 2025JulNovMar 2026Jul42615121321917153616223329346
Hover for who · click for detailEnd-of-day closing prices52w $10.93 – $37.84

Top institutional holders

107 tracked 13F filers
#FundPosition valueSharesLast moveAs ofHistory
1RA CAPITAL MANAGEMENT, L.P.
$168.1M
7.0M
Held
Q1 2026
2Samsara BioCapital, LLC
$75.7M
3.1M
Held
Q1 2026
3GOLDMAN SACHS GROUP INC
$69.8M
2.9M
+7.0%
Added · +191K sh
Q1 2026
4Siren, L.L.C.
$48.1M
2.0M
Held
Q1 2026
5BlackRock, Inc.
$43.8M
1.8M
+1.1%
Added · +21K sh
Q1 2026
6BVF INC/IL
$32.5M
1.4M
−21%
Reduced · −368K sh
Q1 2026
7Avoro Capital Advisors LLC
$32.1M
1.3M
Held
Q1 2026
8VANGUARD CAPITAL MANAGEMENT LLC
$28.8M
1.2M
New
+1.2M sh
Q1 2026
9ADAR1 Capital Management, LLC
$26.2M
1.1M
−5.8%
Reduced · −68K sh
Q1 2026
10PRIMECAP MANAGEMENT CO/CA/
$25.2M
1.0M
+92%
Added · +503K sh
Q1 2026
11JANUS HENDERSON GROUP PLC
$21.3M
891K
New
+891K sh
Q1 2026
12First Light Asset Management, LLC
$17.6M
733K
+18%
Added · +112K sh
Q1 2026
13GEODE CAPITAL MANAGEMENT, LLC
$15.5M
645K
+13%
Added · +72K sh
Q1 2026
14STATE STREET CORP
$15.2M
631K
+17%
Added · +91K sh
Q1 2026
15Casdin Capital, LLC
$13.3M
553K
Held
Q1 2026
16Venrock Adviser, LLC
$12.2M
506K
−17%
Reduced · −105K sh
Q1 2026
17Catalio Capital Management, LP
$7.1M
294K
Held
Q1 2026
18Soleus Capital Management, L.P.
$6.6M
275K
−28%
Reduced · −108K sh
Q1 2026
19BALYASNY ASSET MANAGEMENT L.P.
$5.7M
237K
66×
Added · +233K sh
Q1 2026
20Universal- Beteiligungs- und Servicegesellschaft mbH
$5.4M
224K
+0.6%
Added · +1K sh
Q1 2026
21VANGUARD PORTFOLIO MANAGEMENT LLC
$4.7M
195K
New
+195K sh
Q1 2026
22Kalehua Capital Management LLC
$4.7M
195K
Held
Q1 2026
23CHARLES SCHWAB INVESTMENT MANAGEMENT INC
$4.4M
182K
−3.0%
Reduced · −6K sh
Q1 2026
24NORTHERN TRUST CORP
$4.0M
165K
+6.7%
Added · +10K sh
Q1 2026
25VANGUARD FIDUCIARY TRUST CO
$3.7M
154K
New
+154K sh
Q1 2026

Holders and values reflect the 13F filers Arkolith currently tracks, not the entire institutional universe. Counts and totals are a floor, not the full institutional ownership.

Fund activity: latest quarter

Opened (NEW)
12
funds
Added
18
funds
Reduced
16
funds
Exited
0
funds

Funds that own SEPN also own

CompanyCo-held byCombined value
MIRUM PHARMACEUTICALS INCMIRM34 funds$345.1M
DYNE THERAPEUTICS INCDYN34 funds$232.6M
MICROSOFT CORPMSFT33 funds$18.6B
AMAZON.COM INCAMZN33 funds$14.4B
BROADCOM INCAVGO33 funds$10.7B
META PLATFORMS INC-CLASS AMETA33 funds$8.8B
MICRON TECHNOLOGY INCMU33 funds$5.7B
ELI LILLY & COLLY33 funds$4.3B
UNITED THERAPEUTICS CORPUTHR33 funds$2.2B
INTUITIVE SURGICAL INCISRG33 funds$1.9B
REVOLUTION MEDICINES INCRVMD33 funds$1.1B
DANAHER CORPDHR33 funds$1.0B

Ranked by how many of SEPN's institutional holders also hold each name, a cross-fund conviction signal.

Insider activity (Form 4)

Full insider page →
Buys · 180d
$0
0 insiders
Sells · 180d
$3.8M
3 insiders
Net
-$3.8M
18 P/S txns
Signal
Net Selling
open-market
DateInsiderRoleActionSharesValue
Jul 15, 2026Bhatt ElizabethPresident and COOSell (S)4K$136K
Jul 1, 2026Long Daniel D.SVP, Drug DiscoverySell (S)1K$43K
Jul 1, 2026Long Daniel D.SVP, Drug DiscoverySell (S)2K$72K
Jun 29, 2026Shaikhly SamiraChief People OfficerSell (S)2K$77K
Jun 22, 2026Long Daniel D.SVP, Drug DiscoverySell (S)7K$252K
Jun 22, 2026Long Daniel D.SVP, Drug DiscoverySell (S)8K$281K
Jun 12, 2026Shaikhly SamiraChief People OfficerSell (S)6K$219K
Jun 1, 2026Shaikhly SamiraChief People OfficerSell (S)2K$47K
Jun 1, 2026Shaikhly SamiraChief People OfficerSell (S)1K$39K
Jun 1, 2026Shaikhly SamiraChief People OfficerSell (S)3K$86K
May 26, 2026Shaikhly SamiraChief People OfficerSell (S)12K$355K
Apr 15, 2026Bhatt ElizabethPresident and COOSell (S)326$8K

Institutional ownership over time

107 funds+50 since Q4 2024
054107Q4 2024Q1 2025Q2 2025Q3 2025Q4 2025Q1 2026
funds holding aggregate valuelatest $735.5M

Recent filings

15 shown

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Ask your agent what changed in SEPN

This stock page is the public Follow view. For one current, evidence-backed answer, use capital_change_brief through REST or MCP. It compares tracked 13F changes with qualifying Form 4 activity and cites the SEC evidence.

Copy-paste
curl -H "Authorization: Bearer YOUR_API_KEY" \
  "https://arkolith.com/api/v1/stocks/SEPN/capital-change-brief"
Ask your agent
Use Arkolith's capital_change_brief for SEPN.
Tell me what changed, whether insider activity
corroborates it, and cite the SEC evidence.

13F holdings + Form 4 insider transactions + end-of-day price history + the live filing stream, joined for SEPN. Filings are public domain, sourced to SEC EDGAR; price series derived from end-of-day closes.